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| Product Name | FK506 |
| Description |
FKBP inhibitor |
| Purity | >98% |
| CAS No. | 104987-11-3 |
| Molecular Formula | C44H69HO12 |
| Molecular Weight | 804.02 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in ethanol, and to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OCCCC2=CN=CC=C2 |
| InChI | InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)4 |
| InChIKey | QJJXYPPXXYFBGM-LFZNUXCKSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H301 Precautionary Phrases: P301 + P310 |
| Cite This Product | FK506 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-214) |
Biological Description
| Alternative Names | 3-(3-Pyridinyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)prolinate, Tacrolimus, Fujimycin |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 445643 |
| Scientific Background | FK506, also known as Tacrolimus or Fujimycin, is a macrolide immunosuppressant with emerging neuroprotective properties. It inhibits calcineurin by forming a complex with FKBP12, thereby preventing NF-AT dephosphorylation and downstream T-cell activation. In neuroscience, FK506 has shown promise in protecting neurons from degeneration in models of antiretroviral toxic neuropathy and other neuroinflammatory conditions. Its ability to modulate calcium signaling and reduce neuroinflammation positions it as a potential therapeutic agent for neurodegenerative diseases. |
| References |
1. Nanette B., et al. (2004) J Am Acad Derm. 51(5): 760-766. 2. Ganong W.F., Review of Medical Physiology (22nd ed.) Lange Medical Books. P.530 3. Liu J. Lane W., Friedman J, Weissman I and Schreiber S. (1991) Cell. 66(4): 807-815 |
Product Images
Chemical structure of FK506 (SIH-214), a FKBP inhibitor. CAS #: 109581-93-3. Molecular Formula: C44H69NO12 · H2O. Molecular Weight: 804.02 g/mol.
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