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| Product Name | Garcinol |
| Description |
HAT inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 78824-30-3 |
| Molecular Formula | C38H50O6 |
| Molecular Weight | 602.8 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | CC(=CC[C@@H]1C[C@@]2(C(=C(C(=O)[C@@](C2=O)(C1(C)C)CC=C(C)C)C(=O)C3=CC(=C(C=C3)O)O)O)C[C@H](CC=C(C)C)C(=C)C)C |
| InChI | InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-41H,7,13,15,18,20-21 |
| InChIKey | DTTONLKLWRTCAB-UDFURZHRSA-N |
| Safety Phrases |
Classification: Caution- Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | Garcinol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-355) |
Biological Description
| Alternative Names | Camboginol, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-bicyclo[3.3.1]non-3-ene-2,9-dione |
| Research Areas | Cell Signaling |
| PubChem ID | 5490884 |
| Scientific Background |
Garcinol is a natural, cell-permeable inhibitor of histone acetyltransferases p300 and pCAF (IC₅₀ = 7 µM and 5 µM, respectively). It induces apoptosis, promotes hematopoietic stem cell expansion, and exhibits anti-inflammatory properties. In neuroscience, Garcinol has been shown to promote neurogenesis in cortical progenitor cells and suppress neuroinflammation in Alzheimer’s models by modulating NF-κB signaling. Its ability to regulate histone acetylation and transcriptional activity positions it as a promising compound for exploring epigenetic therapies in neurodegenerative diseases. |
| References |
1. Balasubramanyam K., et al., (2004) J. Biol. Chem. 279: 33716. 2. Parasramka M.A., et al. (2011) Nutr. Cancer. 63: 456. 3. Nishino T., et al. (2011) Nutr. PLoS One 6: e24298. |
Product Images
Chemical structure of Garcinol (SIH-355), a HAT inhibitor. CAS #: 78824-30-3. Molecular Formula: C38H50O6. Molecular Weight: 602.8 g/mol.
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