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| Product Name | GDC 0941 |
| Description |
pan-PI3K kinase inhibitor |
| Purity | >98% |
| CAS No. | 957054-30-7 |
| Molecular Formula | C23H27N7O3S2 |
| Molecular Weight | 513.63 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6 |
| InChI | InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27) |
| InChIKey | LHNIIDJUOCFXAP-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | GDC 0941 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-501) |
Biological Description
| Alternative Names | Pictrelisib, Pictilisib, GNE 0941, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 17755052 |
| Scientific Background | GDC 0941 is a potent and selective inhibitor of class I phosphoinositide 3-kinases (PI3Ks), including PI3Kα, β, δ, and γ isoforms. While primarily investigated in oncology for its role in inhibiting tumor growth and survival pathways, PI3K signaling is also critical in neuronal function, synaptic plasticity, and neuroinflammation. GDC 0941’s modulation of PI3K pathways presents potential applications in neurodegenerative disease models, particularly those involving dysregulated cell survival and neuroimmune responses. |
| References | 1. Zheng J., Wang H., Yao J., & Zou X. (2014) Die Pharmazie. 69(1): 38–42. |
Product Images
Chemical structure of GDC 0941 (SIH-501), a pan-PI3K kinase inhibitor. CAS #: 957054-30-7. Molecular Formula: C23H27N7O3S2. Molecular Weight: 513.63 g/mol.
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