GDC 0941

pan-PI3K kinase inhibitor

Catalog No. SIH-501

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CAS No. 957054-30-7
Molecular Formula C23H27N7O3S2
SKU: SIH-501 Categories: ,

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SIH-501_GDC-0941_Chemical_Structure.png
Product Name GDC 0941
Description

pan-PI3K kinase inhibitor

Purity >98%
CAS No. 957054-30-7
Molecular Formula C23H27N7O3S2
Molecular Weight 513.63
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO
Source Synthetic
Appearance White solid
SMILES CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6
InChI InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)
InChIKey LHNIIDJUOCFXAP-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product GDC 0941 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-501)

Biological Description

Alternative Names Pictrelisib, Pictilisib, GNE 0941, 2-​(1H-​indazol-​4-​yl)-​6-​[[4-​(methylsulfonyl)-​1-​piperazinyl]methyl]-​4-​(4-​morpholinyl)-​thieno[3,​2-​d]pyrimidine
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 17755052
Scientific Background GDC 0941 is a potent and selective inhibitor of class I phosphoinositide 3-kinases (PI3Ks), including PI3Kα, β, δ, and γ isoforms. While primarily investigated in oncology for its role in inhibiting tumor growth and survival pathways, PI3K signaling is also critical in neuronal function, synaptic plasticity, and neuroinflammation. GDC 0941’s modulation of PI3K pathways presents potential applications in neurodegenerative disease models, particularly those involving dysregulated cell survival and neuroimmune responses.
References 1. Zheng J., Wang H., Yao J., & Zou X. (2014) Die Pharmazie. 69(1): 38–42.

Product Images

<p>Chemical structure of GDC 0941 (SIH-501), a pan-PI3K kinase inhibitor. CAS #: 957054-30-7. Molecular Formula: C23H27N7O3S2. Molecular Weight: 513.63 g/mol.</p>

Chemical structure of GDC 0941 (SIH-501), a pan-PI3K kinase inhibitor. CAS #: 957054-30-7. Molecular Formula: C23H27N7O3S2. Molecular Weight: 513.63 g/mol.

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