Gefitinib

EGFR Kinase inhibitor

Catalog No. SIH-445

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CAS No. 184475-35-2
Molecular Formula C22H24ClFN4O3
SKU: SIH-445 Categories: ,

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SIH-445_Gefitinib_Chemical_Structure.png
Product Name Gefitinib
Description

EGFR Kinase inhibitor

Purity >99%
CAS No. 184475-35-2
Molecular Formula C22H24ClFN4O3
Molecular Weight 446.9
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C), DMF (20 mg/ml), and water (<1 mg/ml at 25 °C)
Source Synthetic
Appearance Solid
SMILES C1=C3C(=CC(=C1OC)OCCCN2CCOCC2)C(=NC=N3)NC4=CC=C(C(=C4)Cl)F
InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
InChIKey XGALLCVXEZPNRQ-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Gefitinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-445)

Biological Description

Alternative Names N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 123631
Scientific Background Gefitinib is a selective inhibitor of EGFR tyrosine kinase that blocks receptor autophosphorylation. In neurodegenerative disease research, Gefitinib is used to investigate the role of EGFR signaling in glial activation, neuroinflammation, and neuronal survival. EGFR dysregulation has been associated with neurodegenerative conditions such as Alzheimer’s disease and glioblastoma. Gefitinib’s ability to modulate EGFR activity provides insights into therapeutic strategies targeting receptor-mediated signaling in the central nervous system.
References 1. Ciardiello F., et al. (2000) Clin. Cancer Res. 6(5): 2053–2063.

Product Images

<p>Chemical structure of Gefitinib (SIH-445), a EGFR-Kinase inhibitor. CAS #: 184475-35-2. Molecular Formula: C22H24ClFN4O3. Molecular Weight: 446.9 g/mol.</p>

Chemical structure of Gefitinib (SIH-445), a EGFR-Kinase inhibitor. CAS #: 184475-35-2. Molecular Formula: C22H24ClFN4O3. Molecular Weight: 446.9 g/mol.

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