Gemcitabine HCl

DNA polymerase inhibitor

Catalog No. SIH-623

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CAS No. 122111-03-9
Molecular Formula C9H11F2N3O4 • HCl
SKU: SIH-623 Categories: ,

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SIH-623-Gemcitabine-Chemical-Structure
Product Name Gemcitabine HCl
Description

DNA polymerase inhibitor

Purity >98% (HPLC); NMR (conforms)
CAS No. 122111-03-9
Molecular Formula C9H11F2N3O4 • HCl
Molecular Weight 299.7
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (20 mg/ml); or Water (25 mg/ml)
Source Synthetic
Appearance Off-white powder
SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.Cl
InChI InChI=1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
InChIKey OKKDEIYWILRZIA-OSZBKLCCSA-N
Safety Phrases Classification: Danger. Hazard Statements: H360. Precautionary Statements: P201 - P202 - P280 - P308 + P313 - P405 - P501
Cite This Product Gemcitabine HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-623)

Biological Description

Alternative Names 2′-Deoxy-2′,2′-difluorocytidine hydrochloride; dFdC
Research Areas Cancer, Cell Signaling, DNA Synthesis, DNA/RNA, Epigenetics and Nuclear Signaling, Topoisomerases
PubChem ID 60749
Scientific Background Gemcitabine HCl is a nucleoside analog used as an anticancer agent. It inhibits DNA polymerase and ribonucleotide reductase, leading to apoptosis. While primarily studied in oncology, its mechanisms of DNA synthesis inhibition and cell cycle arrest are relevant to neuroscience research, particularly in models of cytotoxic stress, DNA damage response, and neurodegeneration.
References 1. Mini E., et al. (2006) Ann. Oncol. 17 Suppl 5:v7.
2. Heinemann V., et al. (1995) Semin. Oncol. 22(4 Suppl 11):11.
3. Heinemann V., et al. (1992) Cancer Res. 52:533.
4. Pourquier P., et al. (2002) Clin. Cancer Res. 8:2499.

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