GW5074

c-Raf1 kinase inhibitor

Catalog No. SIH-451

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CAS No. 220904-83-6
Molecular Formula C15H8Br2INO2
SKU: SIH-451 Categories: ,

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SIH-451_GW-5074_Chemical_Structure.png
Product Name GW5074
Description

c-Raf1 kinase inhibitor

Purity >98% (TLC)
CAS No. 220904-83-6
Molecular Formula C15H8Br2INO2
Molecular Weight 520.9
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 1 mM in ethanol and to 100 mM in DMSO
Source Synthetic
Appearance Yellow to orange solid
SMILES C1=CC2=C(C=C1I)/C(=C/C3=CC(=C(C(=C3)Br)O)Br)/C(=O)N2
InChI InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
InChIKey LMXYVLFTZRPNRV-KMKOMSMNSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product GW5074 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-451)

Biological Description

Alternative Names 3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 5924208
Scientific Background GW5074 is a potent and selective inhibitor of c-Raf1 kinase, showing over 100-fold selectivity over other kinases such as CDK1, ERK2, and VEGFR2. In neuroscience, GW5074 is used to study Raf/MEK/ERK signaling in neuronal survival, differentiation, and apoptosis. It has been shown to block low potassium-induced cell death and prevent neurodegeneration. GW5074’s ability to modulate MAPK signaling makes it a key compound for exploring neuroprotective mechanisms and therapeutic targets in neurodegenerative diseases.
References 1. Chin P.C., et al. (2004) J. Neurochem. 90(3): 595–608.
2. Lackey K., et al. (2000). Bioorganic Med. Chem. Ltr. 10(3): 223–226.
3. Chang M.S., (2005). Cell Signal. 17(3): 299–310.

Product Images

<p>Chemical structure of GW5074  (SIH-451), a c-Raf1 kinase inhibitor. CAS #: 220904-83-6. Molecular Formula: C15H8Br2INO2. Molecular Weight: 520.9 g/mol.</p>

Chemical structure of GW5074 (SIH-451), a c-Raf1 kinase inhibitor. CAS #: 220904-83-6. Molecular Formula: C15H8Br2INO2. Molecular Weight: 520.9 g/mol.

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