Hexyl Pentynoic Acid (HPA)

HDAC inhibitor

Catalog No. SIH-356

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CAS No. 96017-59-3
Molecular Formula C11H11O2
SKU: SIH-356 Categories: ,

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SIH-356_Hexyl-4-pentynoic_Acid_Chemical_Structure.png
Product Name Hexyl Pentynoic Acid (HPA)
Description

HDAC inhibitor

Purity >97% (TLC), NMR conforms
CAS No. 96017-59-3
Molecular Formula C11H11O2
Molecular Weight 182.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol
Source Synthetic
Appearance Colorless Oil
SMILES O=C(O)C(CCCCCC)CC#C
InChI InChI=1S/C11H18O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h2,10H,3,5-9H2,1H3,(H,12,13)
InChIKey DUQSBRQHALCSLC-UHFFFAOYSA-N
Safety Phrases Classification: Caution- Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product HPA (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-356)

Biological Description

Alternative Names 2-(2-propynyl)octanoic acid, HPA
Research Areas Cancer, Cell Signaling
PubChem ID 175664
Scientific Background HPA (Hypothalamic-Pituitary-Adrenal axis) refers to a complex neuroendocrine system that regulates stress responses through the release of cortisol and other glucocorticoids. Dysregulation of the HPA axis is associated with chronic stress, depression, and neurodegenerative diseases. In neuroscience, HPA axis activity is studied to understand its impact on hippocampal function, neurogenesis, and neuroinflammation. Elevated glucocorticoid levels can exacerbate neuronal damage and cognitive impairment, making HPA axis modulation a target for therapeutic intervention in brain disorders.
References 1. Eikel D., et al. (2006) Chem. Res. Toxicol. 19: 272.
2. Leng Y., et al. (2010) Neurosci. Lett. 476: 127.

Product Images

<p>Chemical structure of Hexyl-4-pentynoic Acid (SIH-356), a HDAC inhibitor. CAS #: 96017-59-3. Molecular Formula: C11H11O2. Molecular Weight: 182.3 g/mol.</p>

Chemical structure of Hexyl-4-pentynoic Acid (SIH-356), a HDAC inhibitor. CAS #: 96017-59-3. Molecular Formula: C11H11O2. Molecular Weight: 182.3 g/mol.

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