Imatinib mesylate

Kinase inhibitor

Catalog No. SIH-453

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CAS No. 152459-95-5
Molecular Formula C30H35N7O4S
SKU: SIH-453 Categories: ,

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SIH-453_Imatinib_mesylate_Chemical_Structure.png
Product Name Imatinib mesylate
Description

Kinase inhibitor

Purity >98% (HPLC)
CAS No. 152459-95-5
Molecular Formula C30H35N7O4S
Molecular Weight 589.7
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble H2O: soluble10 mg/ml, clear
Source Synthetic
Appearance White to beige solid
SMILES C5=C(C1=CN=CC=C1)N=C(NC2=C(C=CC(=C2)NC(C3=CC=C(C=C3)CN4CCN(CC4)C)=O)C)N=C5
InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
InChIKey KTUFNOKKBVMGRW-UHFFFAOYSA-N
Safety Phrases Classification:
Acute toxicity, Oral (Category 4), H302

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H302 Harmful if swallowed.

Precautionary statements:
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product Imatinib mesylate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-453)

Biological Description

Alternative Names 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide methanesulfonate, 4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide mesylate, CGP 57148, Genfatinib, Glivec, Imatinib methanesulfonate, STI-571
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 5291
Scientific Background Imatinib Mesylate is a tyrosine kinase inhibitor that selectively targets Bcr-Abl, c-Kit, and platelet-derived growth factor receptors (PDGFR). While primarily used in oncology, Imatinib has gained interest in neuroscience for its potential to modulate neuroinflammatory and neurodegenerative pathways. PDGFR signaling is involved in blood-brain barrier integrity, glial activation, and neuronal survival. Inhibition of PDGFR by Imatinib may reduce neuroinflammation and protect against neuronal damage in models of stroke, multiple sclerosis, and Alzheimer's disease. Its ability to cross the blood-brain barrier and influence kinase-driven signaling cascades makes it a valuable tool for exploring therapeutic strategies in neurodegenerative disease research.
References 1. Kantarjian H., et al. (2002). N.E. J. Med. 346(9): 645–652.

Product Images

<p>Chemical structure of Imatinib mesylate (SIH-453), a BCR-ABL kinase inhibitor. CAS #: 152459-95-5. Molecular Formula: C30H35N7O4S. Molecular Weight: 589.7 g/mol.</p>

Chemical structure of Imatinib mesylate (SIH-453), a BCR-ABL kinase inhibitor. CAS #: 152459-95-5. Molecular Formula: C30H35N7O4S. Molecular Weight: 589.7 g/mol.

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