IOX1

JMJD inhibitor

Catalog No. SIH-377

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CAS No. 5852-78-8
Molecular Formula C10H7NO3
SKU: SIH-377 Categories: ,

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SIH-377_IOX1_Chemical_Structure.png
Product Name IOX1
Description

JMJD inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 5852-78-8
Molecular Formula C10H7NO3
Molecular Weight 189.2
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (20 mg/ml)
Source Synthetic
Appearance Yellow powder
SMILES C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O
InChI InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
InChIKey JGRPKOGHYBAVMW-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product IOX1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-377)

Biological Description

Alternative Names 8-Hydroxy-5-quinolinecarboxylic acid; (5-Carboxy-8HQ)
Research Areas Cell Signaling
PubChem ID 459617
Scientific Background IOX1 is a broad-spectrum inhibitor of 2-oxoglutarate-dependent dioxygenases, including histone demethylases. In neuroscience, IOX1 is used to investigate epigenetic regulation of gene expression in neuronal cells. Epigenetic modifications play a crucial role in neurodevelopment, synaptic plasticity, and the pathogenesis of neurodegenerative diseases. By inhibiting histone demethylation, IOX1 alters chromatin structure and transcriptional activity, providing insights into the molecular mechanisms underlying memory formation, neuroinflammation, and neuronal survival. Its utility in epigenetic studies makes it a valuable tool for exploring therapeutic strategies targeting chromatin remodeling in the brain.
References 1. King O.N., et al. (2010) PLoS One. 5: e15535.

Product Images

<p>Chemical structure of IOX1 (SIH-377), a JMJD inhibitor. CAS #: 5852-78-8. Molecular Formula: C10H7 NO3. Molecular Weight: 189.2 g/mol.</p>

Chemical structure of IOX1 (SIH-377), a JMJD inhibitor. CAS #: 5852-78-8. Molecular Formula: C10H7 NO3. Molecular Weight: 189.2 g/mol.

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