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| Product Name | Isradipine |
| Description |
L-type Ca channel blocker |
| Purity | >98% |
| CAS No. | 75695-93-1 |
| Molecular Formula | C19H21N3O5 |
| Molecular Weight | 371.39 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 50 mM in DMSO and to 20 mM in ethanol |
| Source | Synthetic |
| Appearance | Yellow Crystalline Solid |
| SMILES | CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC |
| InChI | InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3 |
| InChIKey | HMJIYCCIJYRONP-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302-H315-H317-H318-H335 Precautionary Phrases: P261-P280-P305 + P351 + P338 |
| Cite This Product | Isradipine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-314) |
Biological Description
| Alternative Names | Isopropyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate, PN 200-110 |
| Research Areas | Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels |
| PubChem ID | 3784 |
| Scientific Background | Isradipine is a dihydropyridine calcium channel blocker with antihypertensive properties. Recent studies suggest its potential use in Parkinson’s disease due to its ability to inhibit L-type calcium channels in dopaminergic neurons. By reducing calcium-induced stress in these neurons, isradipine may slow neurodegeneration and has been evaluated in clinical trials for disease-modifying effects. Its neuroprotective profile makes it a promising candidate in neurodegenerative disease research. |
| References |
1. Wada Y., Satoh K., Taira N. (1985) J Cardiovasc Pharmacol. 7(1): 190-196. 2. Chan C.S., et al. (2007) Nature. 447: 1081-1086. |
Product Images
Chemical structure of Isradipine (SIH-314), a L-type Ca channel blocker. CAS #: 75695-93-1. Molecular Formula: C19H21N3O5. Molecular Weight: 371.39 g/mol.
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