K252A

Kinase inhibitor

Catalog No. SIH-455

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CAS No. 99533-80-9
Molecular Formula C27H21N3O5
SKU: SIH-455 Categories: ,

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SIH-455_K252A_Chemical_Structure.png
Product Name K252A
Description

Kinase inhibitor

Purity >98% (HPLC)
CAS No. 99533-80-9
Molecular Formula C27H21N3O5
Molecular Weight 467.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 25 mM in DMSO
Source Nonomuraea longicatena
Appearance White solid
SMILES [N]47C1=C(C6=C(C2=C1[N](C3=CC=CC=C23)[C@@H]5O[C@]4(C(C5)(O)C(=O)OC)C)C(NC6)=O)C8=C7C=CC=C8
InChI InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18?,26-,27-/m1/s1
InChIKey KOZFSFOOLUUIGY-CYBHFKQVSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product K252A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-455)

Biological Description

Alternative Names (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 11612445
Scientific Background K252A is a broad-spectrum protein kinase inhibitor that targets a wide range of kinases, including PKA, PKC, PKG, CaM kinase II, myosin light chain kinase (mlCK), and receptor tyrosine kinases. In neuroscience, K252A is widely used to study neurotrophic signaling, particularly through its inhibition of TrkA, the receptor for nerve growth factor (NGF). It is employed in models of neuronal differentiation, survival, and synaptic plasticity. K252A is also used to investigate the role of kinase signaling in neurodegenerative processes and to explore therapeutic strategies targeting kinase dysregulation in the brain.
References 1. Morotti A., Mila S., Accorner, P., Tagliabue E., & Ponzetto C. (2002) Oncogene. 21(32): 4885–4893.
2. Hashimoto Y., et al. (1991) Biochem. Biophys. Res. Comm. 181(1): 423–429.
3. Raychaudhuri S.P., Sanyal M., Weltman H., & Kundu-Raychaudhuri S. (2004) J. Invest. Derm. 122(3): 812–819.

Product Images

<p>Chemical structure of K252A (SIH-455), a Kinase inhibitor (pan-specific). CAS #: 99533-80-9. Molecular Formula: C27H21N3O5. Molecular Weight: 467.5 g/mol.</p>

Chemical structure of K252A (SIH-455), a Kinase inhibitor (pan-specific). CAS #: 99533-80-9. Molecular Formula: C27H21N3O5. Molecular Weight: 467.5 g/mol.

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