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| Product Name | K252B |
| Description |
Kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 99570-78-2 |
| Molecular Formula | C26H19N3O5 |
| Molecular Weight | 453.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml) |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | C[C@]12[C@@](C[C@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O |
| InChI | InChI=1S/C26H19N3O5/c1-25-26(33,24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9,17,33H,10-11H2,1H3,(H,27,30)(H,31,32)/t17-,25+,26+/m1/s1 |
| InChIKey | AMSOPBXQXSAAAC-PLZPTFKGSA-N |
| Safety Phrases |
Classification: Flammable liquids (Category 4), H227 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H227 Combustible liquid Precautionary statements: P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol - resistant foam for extinction. P403 + P235 Store in a well - ventilated place. Keep cool. P501 Dispose of contents/ container to an approved waste disposal plant |
| Cite This Product | K252B (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-456) |
Biological Description
| Alternative Names | (9S,10R,12R)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 9981344 |
| Scientific Background | K252B is a non-selective protein kinase inhibitor that targets CaMKII, MYLK, PKA, PKC, and cGKI by binding to the ATP-binding domain of these kinases. It is cell-permeable and used in neuroscience to study the regulation of intracellular signaling pathways involved in synaptic transmission, plasticity, and neuronal survival. K252B is particularly useful in dissecting the roles of calcium/calmodulin-dependent kinases and cyclic nucleotide-dependent kinases in neurodevelopment and neurodegeneration. |
| References |
1. Nakanishi S., Matsuda Y., Iwahashi K., & Kase H. (1986) J. Antibiotics 39(8): 1066–1071. 2. Teshima R., et al. (1997) J. Immun. 159(2): 964–969. 3. Knüsel B., et al. (1992) J. Neurochem. 59(2): 715–722. |
Product Images
Chemical structure of K252B (SIH-456), a Kinase inhibitor (pan-specific). CAS #: 99570-78-2. Molecular Formula: C26H19N3O5. Molecular Weight: 453.5 g/mol.
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