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| Product Name | KNK 437 |
| Description |
HSP70 Inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 218924-25-5 |
| Molecular Formula | C13H11NO4 |
| Molecular Weight | 245.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (30 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | C1CN(C(=O)C1=CC2=CC3=C(C=C2)OCO3)C=O |
| InChI | InChI=1S/C13H11NO4/c15-7-14-4-3-10(13(14)16)5-9-1-2-11-12(6-9)18-8-17-11/h1-2,5-7H,3-4,8H2/b10-5+ |
| InChIKey | LZGGUFLRKIMBDQ-BJMVGYQFSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | KNK 437 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-599) |
Biological Description
| Alternative Names | 3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde |
| Research Areas | Cancer, Heat Shock |
| PubChem ID | 46195007 |
| Scientific Background | KNK 437 is a small-molecule inhibitor of heat shock protein (HSP) expression, including HSP70, HSP40, and HSP105. It blocks the acquisition of thermotolerance and has been investigated in cancer therapy for its ability to sensitize cells to stress. In neuroscience, HSPs play a critical role in protein folding, aggregation prevention, and cellular stress responses. KNK 437 is used to study the role of HSPs in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, where protein misfolding and aggregation are central pathological features. |
| References | 1. Yokota S., Kitahara M., and Nagata K. (2000) Cancer Res. 60 (11): 2942-2948. 2. Yang S., et al. (2020) Oncogene. 39: 249-261. |
Product Images
Chemical structure of KNK 437 (SIH-599), a HSP70 Inhibitor. CAS #: 218924-25-5. Molecular Formula: C13H11NO4. Molecular Weight: 245.2 g/mol.
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