Product Name | KT5720 |
Description |
PKA kinase inhibitor |
Purity | >98% (TLC) |
CAS No. | 108068-98-0 |
Molecular Formula | C32H31N3O5 |
Molecular Weight | 537.6 |
Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Storage Temperature | -20ºC |
Shipping Temperature | Shipped Ambient |
Product Type | Inhibitor |
Solubility | Soluble in methanol: clear colorless solution at 5 mg/ml |
Source | Synthetic |
Appearance | White powder |
SMILES | [N]47C1=C(C6=C(C2=C1[N](C3=CC=CC=C23)[C@H]5O[C@@]4([C@](C5)(O)C(=O)OCCCCCC)C)C(NC6)=O)C8=C7C=CC=C8 |
InChI | InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,3 |
InChIKey | ZHEHVZXPFVXKEY-UHFFFAOYSA-N |
Safety Phrases |
Classification: Specific target organ toxicity-single exposure (Category 1), H370 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H370 Causes damage to organs. Precautionary statements: P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P307 + P311 IF exposed: Call a POISON CENTER or doctor/ physician. P321 Specific treatment (see supplemental first aid instructions on this label). P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant |
Cite This Product | KT5720 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-457) |
Alternative Names | (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester |
Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
PubChem ID | 3844 |
Scientific Background | KT5720 is a potent and selective inhibitor of protein kinase A (PKA), acting through competitive inhibition. It does not significantly affect PKC, PKG, or mlCK, making it a valuable tool for studying PKA-specific signaling pathways. In neuroscience, KT5720 is used to investigate the role of PKA in synaptic plasticity, memory formation, and neuronal survival. It is also employed in studies of cell cycle regulation and neuroprotection, particularly in models of neurodegenerative disease. |
References |
1. Kase H., et al. (1987) Biochem. Biophys. Res. Comm. 142(2): 436–440. 2. Gadbois D.M., Crissman H.A., Tobey R.A., & Bradbury E.M. (1992) Pro. Na. Aca. Sci. USA. 89(18): 8626–8630. |
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