Lapatinib

Dual EGFR/HER2 Tyrosine Kinase Inhibitor

Catalog No. SIH-459

0 out of 5 based on 0 customer ratings
CAS No. 231277-92-2
Molecular Formula C29H26ClFN4O4S
SKU: SIH-459 Categories: ,

Clear
SIH-459_Lapatinib_Chemical_Structure.png
Product Name Lapatinib
Description

Dual EGFR/HER2 Tyrosine Kinase Inhibitor

Purity >99%
CAS No. 231277-92-2
Molecular Formula C29H26ClFN4O4S
Molecular Weight 581.1
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Solubility in water is 0.007 mg/ml and in 0.1N HCl is 0.001 mg/ml at 25° C
Source Synthetic
Appearance Yellow crystalline solid
SMILES C2=C1C(=NC=NC1=CC=C2C3=CC=C(O3)CNCC[S](=O)(=O)C)NC4=CC=C(C(=C4)Cl)OCC5=CC=CC(=C5)F
InChI InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35
InChIKey BCFGMOOMADDAQU-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Lapatinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-459)

Biological Description

Alternative Names N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Growth Factor Receptor Inhibitors
PubChem ID 208908
Scientific Background Lapatinib is a dual tyrosine kinase inhibitor that targets the ErbB2 (HER2) and epidermal growth factor receptor (EGFR) pathways. While primarily used in oncology, Lapatinib has potential applications in neuroscience due to the involvement of EGFR signaling in neuroinflammation, gliosis, and neurodegeneration. It is being explored for its ability to modulate glial cell activity and protect against excitotoxicity in models of Alzheimer's disease and brain injury. Lapatinib’s ability to cross the blood-brain barrier enhances its utility in central nervous system research.
References 1. Chien A.J., et al. (2014) J. Clin. Oncol: J. Am. Clin. Oncol. 32(14): 1472–1479.
2. Dahal B.K., et al. (2010) Am. J. Resp. Critical Care Med. 181(2): 158–167.

Product Images

<p>Chemical structure of Lapatinib (SIH-459), a EGFR and HER2 inhibitor. CAS #: 231277-92-2. Molecular Formula: C29H26ClFN4O4S. Molecular Weight: 581.1 g/mol.</p>

Chemical structure of Lapatinib (SIH-459), a EGFR and HER2 inhibitor. CAS #: 231277-92-2. Molecular Formula: C29H26ClFN4O4S. Molecular Weight: 581.1 g/mol.

Reviews

Reviews

There are no reviews yet.

Be the first to review “Lapatinib”

Your email address will not be published. Required fields are marked *