LDN-57444

DUB inhibitor

Catalog No. SIH-332

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CAS No. 668467-91-2
Molecular Formula C17H11Cl3N2O3
SKU: SIH-332 Categories: ,

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SIH-332_LDN-57444_Chemical_Structure.png
Product Name LDN-57444
Description

DUB inhibitor

Purity >98%
CAS No. 668467-91-2
Molecular Formula C17H11Cl3N2O3
Molecular Weight 397.6
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 20 mg/ml DMSO
Source Synthetic
Appearance Yellow Powder
SMILES CC(=O)O/N=C1/C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl
InChI InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-
InChIKey OPQRFPHLZZPCCH-PGMHBOJBSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H302 – Harmful if swallowed
H317 – May cause an allergic skin reaction
Precautionary Statements:
P280 – Wear protective gloves.
Cite This Product LDN-57444 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-332)

Biological Description

Alternative Names 3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione, C30, LDN 57444
Research Areas Apoptosis, Cancer
PubChem ID 16760696
Scientific Background LDN-57444 inhibits ubiquitin C-terminal hydrolase UCH-L1, decreasing proteasome activity and increasing levels of ubiquitinated proteins. It induces apoptosis and alters synaptic protein distribution and spine morphology. This compound is widely used in neuroscience to study synaptic plasticity, neurodegenerative disease progression, and protein homeostasis.
References 1. Liu Y., et al. (2003) Chem. Biol. 10: 837.
2. Tan Y.Y., et al. (2008) Mol. Cell. Biochem. 318: 109.
3. Cartier A.E., et al. (2009) J.Neurosci. 29: 7857.

Product Images

<p>Chemical structure of LDN-57444 (SIH-332), a DUB inhibitor. CAS #: 668467-91-2. Molecular Formula: C17H11Cl3N2O3. Molecular Weight: 397.6 g/mol.</p>

Chemical structure of LDN-57444 (SIH-332), a DUB inhibitor. CAS #: 668467-91-2. Molecular Formula: C17H11Cl3N2O3. Molecular Weight: 397.6 g/mol.

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