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| Product Name | LDN-57444 |
| Description |
DUB inhibitor |
| Purity | >98% |
| CAS No. | 668467-91-2 |
| Molecular Formula | C17H11Cl3N2O3 |
| Molecular Weight | 397.6 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 20 mg/ml DMSO |
| Source | Synthetic |
| Appearance | Yellow Powder |
| SMILES | CC(=O)O/N=C1/C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl |
| InChI | InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16- |
| InChIKey | OPQRFPHLZZPCCH-PGMHBOJBSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302 – Harmful if swallowed H317 – May cause an allergic skin reaction Precautionary Statements: P280 – Wear protective gloves. |
| Cite This Product | LDN-57444 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-332) |
Biological Description
| Alternative Names | 3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione, C30, LDN 57444 |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 16760696 |
| Scientific Background | LDN-57444 inhibits ubiquitin C-terminal hydrolase UCH-L1, decreasing proteasome activity and increasing levels of ubiquitinated proteins. It induces apoptosis and alters synaptic protein distribution and spine morphology. This compound is widely used in neuroscience to study synaptic plasticity, neurodegenerative disease progression, and protein homeostasis. |
| References |
1. Liu Y., et al. (2003) Chem. Biol. 10: 837. 2. Tan Y.Y., et al. (2008) Mol. Cell. Biochem. 318: 109. 3. Cartier A.E., et al. (2009) J.Neurosci. 29: 7857. |
Product Images
Chemical structure of LDN-57444 (SIH-332), a DUB inhibitor. CAS #: 668467-91-2. Molecular Formula: C17H11Cl3N2O3. Molecular Weight: 397.6 g/mol.
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