Lestaurtinib

FLT3, TrkA kinase inhibitor

Catalog No. SIH-460

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CAS No. 111358-88-4
Molecular Formula C26H21N3O4
SKU: SIH-460 Categories: ,

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SIH-460_Lestaurtinib_Chemical_Structure.png
Product Name Lestaurtinib
Description

FLT3, TrkA kinase inhibitor

Purity >98% (HPLC)
CAS No. 111358-88-4
Molecular Formula C26H21N3O4
Molecular Weight 439.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO and to 25 mM in ethanol
Source Synthetic
Appearance White powder
SMILES [C@@]67([N]2C1=C5C(=C4C(=C1C3=C2C=CC=C3)CNC4=O)C8=C([N]5[C@H](O6)C[C@]7(O)CO)C=CC=C8)C
InChI InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1
InChIKey UIARLYUEJFELEN-LROUJFHJSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Lestaurtinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-460)

Biological Description

Alternative Names KT5555, CEP-701, (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 126565
Scientific Background Lestaurtinib is a potent inhibitor of JAK2, FLT3, and TrkA receptor tyrosine kinases. In neuroscience, it is used to study neurotrophic signaling and inflammatory pathways. By inhibiting TrkA, Lestaurtinib helps elucidate the role of nerve growth factor (NGF) signaling in neuronal survival and differentiation. Its inhibition of JAK2 also makes it relevant in models of neuroinflammation and cytokine signaling. Lestaurtinib is a valuable compound for investigating kinase-driven mechanisms in neurodegenerative diseases.
References 1. Weisel K.C., et al. (2007) Ann. NY Acad. Sci. 1106: 190–196.
2. Hexner E.O., et al. (2008) Blood. 111(12): 5663–5671.

Product Images

<p>Chemical structure of Lestaurtinib (SIH-460), a FLT3/ TrkA kinase inhibitor. CAS #: 111358-88-4. Molecular Formula: C26H21N3O4. Molecular Weight: 439.5 g/mol.</p>

Chemical structure of Lestaurtinib (SIH-460), a FLT3/ TrkA kinase inhibitor. CAS #: 111358-88-4. Molecular Formula: C26H21N3O4. Molecular Weight: 439.5 g/mol.

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