Lovastatin

HMG-CoA reductase inhibitor

Catalog No. SIH-256

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CAS No. 75330-75-5
Molecular Formula C24H36O5
SKU: SIH-256 Categories: ,

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SIH-256_Lovastatin_Chemical_Structure.png
Product Name Lovastatin
Description

HMG-CoA reductase inhibitor

Purity >98%
CAS No. 75330-75-5
Molecular Formula C24H36O5
Molecular Weight 404.54
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 50 mM in ethanol and 100 mM in DMSO
Source Synthetic
Appearance White solid
SMILES CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C
InChI InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18
InChIKey PCZOHLXUXFIOCF-BXMDZJJMSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed, or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62- Possible risk of impaired fertility
Cite This Product Lovastatin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-256)

Biological Description

Alternative Names (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate, Mevinolin
Research Areas Apoptosis, Cancer
PubChem ID 53232
Scientific Background Lovastatin is a member of the statin class of drugs that inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. Beyond its cardiovascular benefits, lovastatin has been investigated for its neuroprotective effects, including anti-inflammatory and antioxidant properties. In neuroscience, it is studied for its potential to modulate amyloid precursor protein processing, reduce neuroinflammation, and improve cognitive function in models of Alzheimer's disease. Its pleiotropic effects make it a candidate for repurposing in neurodegenerative disease research.
References 1. Alberts A.W. (1998) Am J Cardio. 62(15): 10J-15J.

Product Images

<p>Chemical structure of Lovastatin (SIH-256), a HMG-CoA reductase inhibitor. CAS #: 75330-75-5. Molecular Formula: C24H36O5. Molecular Weight: 404.54 g/mol.</p>

Chemical structure of Lovastatin (SIH-256), a HMG-CoA reductase inhibitor. CAS #: 75330-75-5. Molecular Formula: C24H36O5. Molecular Weight: 404.54 g/mol.

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