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| Product Name | Lovastatin |
| Description |
HMG-CoA reductase inhibitor |
| Purity | >98% |
| CAS No. | 75330-75-5 |
| Molecular Formula | C24H36O5 |
| Molecular Weight | 404.54 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 50 mM in ethanol and 100 mM in DMSO |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C |
| InChI | InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18 |
| InChIKey | PCZOHLXUXFIOCF-BXMDZJJMSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed, or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R62- Possible risk of impaired fertility |
| Cite This Product | Lovastatin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-256) |
Biological Description
| Alternative Names | (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate, Mevinolin |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 53232 |
| Scientific Background | Lovastatin is a member of the statin class of drugs that inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. Beyond its cardiovascular benefits, lovastatin has been investigated for its neuroprotective effects, including anti-inflammatory and antioxidant properties. In neuroscience, it is studied for its potential to modulate amyloid precursor protein processing, reduce neuroinflammation, and improve cognitive function in models of Alzheimer's disease. Its pleiotropic effects make it a candidate for repurposing in neurodegenerative disease research. |
| References | 1. Alberts A.W. (1998) Am J Cardio. 62(15): 10J-15J. |
Product Images
Chemical structure of Lovastatin (SIH-256), a HMG-CoA reductase inhibitor. CAS #: 75330-75-5. Molecular Formula: C24H36O5. Molecular Weight: 404.54 g/mol.
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