LY 294002

PI 3-Kinase inhibitor

Catalog No. SIH-252

5.00 out of 5 based on 1 customer rating
CAS No. 154447-36-6
Molecular Formula C19H17NO3•HCl
SKU: SIH-252 Categories: ,

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SIH-252_LY_294002_Chemical_Structure.png
Product Name LY 294002
Description

PI 3-Kinase inhibitor

Purity >98%
CAS No. 154447-36-6
Molecular Formula C19H17NO3•HCl
Molecular Weight 343.81
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 5 mM in ethanol and to 25 mM in DMSO
Source Synthetic
Appearance White Crystalline Solid
SMILES C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4
InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChIKey CZQHHVNHHHRRDU-UHFFFAOYSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product LY 294002 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-252)

Biological Description

Alternative Names 2-(4-Morpholinyl)-8-phenyl-4H-chromen-4-one
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
PubChem ID 3973
Scientific Background LY 294002 is a synthetic small molecule that functions as a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). By blocking PI3K activity, it disrupts the PI3K/Akt signaling pathway, which is critical for cell survival, proliferation, and metabolism. In neuroscience, LY 294002 is widely used to study mechanisms of neuronal apoptosis, synaptic plasticity, and neuroinflammation. Its ability to modulate neurotrophic signaling makes it a valuable tool for investigating neurodegenerative diseases such as Alzheimer's and Parkinson's.
References 1.  Vlahos, et al. (1994) J Biol Chem. 269: 5241.

Product Images

<p>Chemical structure of LY 294002 (SIH-252), a PI 3-Kinase inhibitor. CAS #: 154447-36-6. Molecular Formula: C19H17NO3 * HCl. Molecular Weight: 343.81 g/mol.</p>

Chemical structure of LY 294002 (SIH-252), a PI 3-Kinase inhibitor. CAS #: 154447-36-6. Molecular Formula: C19H17NO3 * HCl. Molecular Weight: 343.81 g/mol.

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