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| Product Name | LY 294002 |
| Description |
PI 3-Kinase inhibitor |
| Purity | >98% |
| CAS No. | 154447-36-6 |
| Molecular Formula | C19H17NO3•HCl |
| Molecular Weight | 343.81 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 5 mM in ethanol and to 25 mM in DMSO |
| Source | Synthetic |
| Appearance | White Crystalline Solid |
| SMILES | C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4 |
| InChI | InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 |
| InChIKey | CZQHHVNHHHRRDU-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | LY 294002 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-252) |
Biological Description
| Alternative Names | 2-(4-Morpholinyl)-8-phenyl-4H-chromen-4-one |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors |
| PubChem ID | 3973 |
| Scientific Background | LY 294002 is a synthetic small molecule that functions as a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). By blocking PI3K activity, it disrupts the PI3K/Akt signaling pathway, which is critical for cell survival, proliferation, and metabolism. In neuroscience, LY 294002 is widely used to study mechanisms of neuronal apoptosis, synaptic plasticity, and neuroinflammation. Its ability to modulate neurotrophic signaling makes it a valuable tool for investigating neurodegenerative diseases such as Alzheimer's and Parkinson's. |
| References | 1. Vlahos, et al. (1994) J Biol Chem. 269: 5241. |
Product Images
Chemical structure of LY 294002 (SIH-252), a PI 3-Kinase inhibitor. CAS #: 154447-36-6. Molecular Formula: C19H17NO3 * HCl. Molecular Weight: 343.81 g/mol.
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Based on validation through cited publications.