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| Product Name | LYS6K2 |
| Description |
S6 kinase inhibitor |
| Purity | 97% (HPLC) |
| Molecular Formula | C21H19F4N7 |
| Molecular Weight | 445.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (up to 1 mg/ml) or DMF (up to 3 mg/ml with warming) |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | Cn1cc(nc1C2CCN(CC2)c3c4cn[nH]c4ncn3)c5ccc(c(c5)C(F)(F)F)F |
| InChI | InChI=1S/C21H19F4N7/c1-31-10-17(13-2-3-16(22)15(8-13)21(23,24)25)29-19(31)12-4-6-32(7-5-12)20-14-9-28-30-18(14)26-11-27-20/h2-3,8-12H,4-7H2,1H3,(H,26,27,28,30) |
| InChIKey | FYXRSVDHGLUMHB-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Skin Category 2 Eye Category 2A Specific target organ toxicity - single exposure (Category 3 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. |
| Cite This Product | LYS6K2 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-462) |
Biological Description
| Alternative Names | 4-(4-(4-(4-fluoro-3-(trifluoromethyl) phenyl)-1-methyl-1H-imidazol-2-yl) piperidin-1-yl)-1H-pyrazolo [3,4-d] pyrimidine |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 25118925 |
| Scientific Background | LYS6K2 is a selective inhibitor of p70 ribosomal S6 kinase (S6K), which plays a critical role in protein synthesis and cell growth downstream of the mTOR pathway. In neuroscience, LYS6K2 is used to study mTOR signaling in neuronal development, synaptic plasticity, and neurodegeneration. By blocking S6 phosphorylation, LYS6K2 helps elucidate the role of translational control in brain aging and neurodegenerative disease progression. Its cell-permeable nature makes it suitable for in vitro and in vivo studies of mTOR-S6K signaling in the nervous system. |
| References | 1. Fenton T.R., & Gout I.T. (2011) Int. J. Biochem. Cell Biol. 43(1): 47–59. |
Product Images
Chemical structure of LYS6K2 (SIH-462), a S6 kinase inhibitor. CAS #: N/A. Molecular Formula: C21H19F4N7. Molecular Weight: 445.4 g/mol.
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