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| Product Name | MDBN |
| Description |
p97 inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 1485-00-3 |
| Molecular Formula | C9H7NO4 |
| Molecular Weight | 193.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 50 mg/ml DMSO |
| Source | Synthetic |
| Appearance | Yellow Solid |
| SMILES | C1OC2=C(O1)C=C(C=C2)/C=C/[N+](=O)[O-] |
| InChI | InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3+ |
| InChIKey | KFLWBZPSJQPRDD-ONEGZZNKSA-N |
| Safety Phrases |
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | MDBN (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-342) |
Biological Description
| Alternative Names | 3,4-Methylenedioxy-β-nitrostyrene; 5-[(E)-2-Nitrovinyl]-1,3-benzodioxole |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 672296 |
| Scientific Background | MDBN is an irreversible inhibitor of the AAA-ATPase p97, also known as valosin-containing protein (VCP), with an IC50 below 10 µM. p97 plays a central role in protein homeostasis, including ER-associated degradation (ERAD), autophagy, and stress granule dynamics. Mutations in p97 are linked to neurodegenerative disorders such as inclusion body myopathy and frontotemporal dementia. MDBN offers a pharmacological approach to modulate p97 activity and investigate its role in neuronal proteostasis and neurodegeneration. |
| References | 1. Chou, T.F., et al. (2011) J Biol Chem. 286: 16546. |
Product Images
Chemical structure of MDBN (SIH-342), a p97 inhibitor. CAS #: 1485-00-3. Molecular Formula: C9H7NO4. Molecular Weight: 193.2 g/mol.
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Based on validation through cited publications.