Midostaurin

Kinase inhibitor

Catalog No. SIH-468

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CAS No. 120685-11-2
Molecular Formula C35H30N4O4
SKU: SIH-468 Categories: ,

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SIH-468_PKC-412_Chemical_Structure.png
Product Name Midostaurin
Description

Kinase inhibitor

Purity >98% (TLC)
CAS No. 120685-11-2
Molecular Formula C35H30N4O4
Molecular Weight 570.6
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml)
Source Synthetic
Appearance White to off-white powder
SMILES [N]48C1=C(C7=C(C2=C1[N](C3=CC=CC=C23)[C@@H]5O[C@]4([C@@]([C@@H]5N(C)C(=O)C6=CC=CC=C6)(OC)C)C)C(NC7)=O)C9=C8C=CC=C9
InChI InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(
InChIKey BMGQWWVMWDBQGC-PZFYLCKJSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Midostaurin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-468)

Biological Description

Alternative Names 4'-N-Benzoyl-staurosporine, PKC-412, CGP 41251
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 24202429
Scientific Background Midostaurin is a broad-spectrum protein kinase inhibitor with activity against PKC isoforms (α, β, γ), Flk, and c-Kit. In neurodegenerative disease research, Midostaurin is used to investigate the role of PKC and related kinases in neuronal signaling, apoptosis, and inflammation. Its ability to induce apoptosis and inhibit proliferative signaling pathways makes it a valuable tool for studying neurodegeneration, particularly in models involving aberrant kinase activity and glial activation.
References 1. Fabbro D., et al. (2000) Anti-Cancer Drug Design. 15(1): 17–28.
2. Odgerel, T., et al. (2008) Oncogene. 27(22): 3102–3110.
3. Bahlis, N.J., et al. (2005) Leukemia & Lymphoma. 46(6): 899–908.

Product Images

<p>Chemical structure of Midostaurin (SIH-468), a Protein kinase inhibitor (pan spec.). CAS #: 120685-11-2. Molecular Formula: C35H30N4O4. Molecular Weight: 570.6 g/mol.</p>

Chemical structure of Midostaurin (SIH-468), a Protein kinase inhibitor (pan spec.). CAS #: 120685-11-2. Molecular Formula: C35H30N4O4. Molecular Weight: 570.6 g/mol.

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