Myriocin (ISP-1)

Palmitoyltransferase inhibitor

Catalog No. SIH-233

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CAS No. 35891-70-4
Molecular Formula C21H39NO6
SKU: SIH-233 Categories: ,

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SIH-233_Myriocin_ISP-1_Chemical_Structure.png
Product Name Myriocin (ISP-1)
Description

Palmitoyltransferase inhibitor

Purity >98%
CAS No. 35891-70-4
Molecular Formula C21H39NO6
Molecular Weight 401.54
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 2 mg/ml of methanol, DMSO (25 mg/ml; heat briefly in boiling water bath) or in dilute base (5 mg/ml; 50 mM NaOH)
Source Synthetic
Appearance Off-White Solid
SMILES CCCCCCC(=O)CCCCCC/C=C/C[C@H]([C@@H]([C@@](CO)(C(=O)O)N)O)O
InChI InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1
InChIKey ZZIKIHCNFWXKDY-GNTQXERDSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label wherepossible)
Risk Phrases:
R22- Harmful if swallowed
Hazard Phrases:
H301
Precautionary Phrases:
P301 + P310
Cite This Product Myriocin (ISP-1) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-233)

Biological Description

Alternative Names (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-icosenoic acid
Research Areas Apoptosis, Cancer
PubChem ID 6438394
Scientific Background Myriocin, also known as ISP-1, is a potent inhibitor of serine palmitoyltransferase, the enzyme responsible for the first step in sphingolipid biosynthesis. In neuroscience, Myriocin is used to study the impact of sphingolipid metabolism on neuronal survival, inflammation, and synaptic function. Its immunosuppressive properties and ability to modulate lipid signaling pathways make it relevant in models of neuroinflammation and neurodegeneration.
References 1. Hidari K.I.P.J., et al. (1996) J Biol Chem. 271: 14636-14641.
2. Miyake Y., Kozutsumi Y., Nakamura S., Fujita T. and Kawasaki T. (1995) Biochem Piophys Res Commun. 211(2): 396-403.

Product Images

<p>Chemical structure of Myriocin (ISP-1) (SIH-233), a Blocks sphingolipid biosynthesis. CAS #: 35891-70-4. Molecular Formula: C21H39NO6. Molecular Weight: 401.54 g/mol.</p>

Chemical structure of Myriocin (ISP-1) (SIH-233), a Blocks sphingolipid biosynthesis. CAS #: 35891-70-4. Molecular Formula: C21H39NO6. Molecular Weight: 401.54 g/mol.

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