MCC-950

NLRP3 inflammasome activation inhibitor

Catalog No. SIH-604

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CAS No. 256373-96-3
Molecular Formula C20H23N2O5S ∙ Na
SKU: SIH-604 Categories: ,

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SIH-604-MCC-950-Chemical-Structure.png
Product Name MCC-950
Description

NLRP3 inflammasome activation inhibitor

Purity >98% (HPLC); NMR (conforms)
CAS No. 256373-96-3
Molecular Formula C20H23N2O5S ∙ Na
Molecular Weight 426.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in water (30 mg/ml): or DMSO (40 mg/ml)
Source Synthetic
Appearance White powder
SMILES COC1=CC=C(C=C1)CC(=O)NC2=CC(=CC=C2)O
InChI InChI=1S/C15H15NO3/c1-19-14-7-5-11(6-8-14)9-15(18)16-12-3-2-4-13(17)10-12/h2-8,10,17H,9H2,1H3,(H,16,18)
InChIKey OTXSEOHBMQFDBM-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Not a hazardous substance or mixture.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product MCC-950 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-604)

Biological Description

Alternative Names N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt; CRID3; CP-456773 sodium salt
Research Areas Cancer, Cell Signaling, Growth Factors, Neurodegeneration, Neuroscience, Parkinson's Disease, Synuclein, TNF
PubChem ID 1234617
Scientific Background MCC-950 is a selective inhibitor of the NLRP3 inflammasome, a key mediator of neuroinflammation. It blocks both canonical and noncanonical NLRP3 activation, reducing IL-1β secretion and attenuating neuroinflammatory responses. MCC-950 has shown therapeutic potential in models of multiple sclerosis and Parkinson’s disease, where inflammasome activation contributes to neuronal damage and disease progression. Its ability to modulate innate immune signaling makes it a promising candidate for neurodegenerative disease research.
References 1. Laliberte R.E. et al. (2003) J. Biol. Chem. 278(19):16567-78.
2. Coll R.C., et al. (2011) PLoS One. 6(12):e29539.
3. Coll R.C., et al. (2015) Nat. Med. 21(3):248-255.
4. Kaneko N., et al. (2015) J. Immunol. Methods. 426:76-81. 5. Nguyen L., et al. (2022) J Parkinsons Dis. 12(7): 2117-2133.

Product Images

<p>Chemical structure of MCC-950 (SIH-604), a NLRP3 inflammasome activation inhibitor. CAS #: 256373-96-3. Molecular Formula: C20H23N2O5S ∙ Na. Molecular Weight: 426.5 g/mol.</p>

Chemical structure of MCC-950 (SIH-604), a NLRP3 inflammasome activation inhibitor. CAS #: 256373-96-3. Molecular Formula: C20H23N2O5S ∙ Na. Molecular Weight: 426.5 g/mol.

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