Discovery through Partnership | Excellence through Quality
| Product Name | Nocodazole |
| Description |
Microtubule inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 31430-18-9 |
| Molecular Formula | C14H11N3O3S |
| Molecular Weight | 301.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (10 mg/ml, warm) |
| Source | Synthetic |
| Appearance | White to off-white powder. |
| SMILES | COC(=O)NC1=NC2=C(N1)C=CC(=C2)C(=O)C3=CC=CS3 |
| InChI | InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19) |
| InChIKey | KYRVNWMVYQXFEU-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H341- Suspected of causing genetic defects. H361d – Suspected of damaging the unborn child Precautionary Phrases: P281 – Use personal protective equipment as required. |
| Cite This Product | Nocodazole (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-367) |
Biological Description
| Alternative Names | Methyl (5-[2-thienylcarbonyl]-1H-benzimidazol-2-yl |
| Research Areas | Apoptosis, Cancer, Neuroscience |
| PubChem ID | 4122 |
| Scientific Background | Nocodazole is a microtubule-depolymerizing agent that disrupts cytoskeletal dynamics by inhibiting tubulin polymerization. In neuroscience, nocodazole is used to study axonal transport, neuronal morphology, and cell cycle regulation. Microtubule integrity is essential for neuronal function, and its disruption is implicated in neurodegenerative diseases such as Alzheimer's and ALS. Nocodazole helps elucidate the role of cytoskeletal organization in synaptic transmission, neurodevelopment, and neurodegeneration. Its application in cellular models provides insights into the mechanisms of neuronal injury and repair. |
| References |
1. Vasquez RJ., Howell B., Yvon AM., Wadsworth P., Cassimus L. (1997) Mol Biol Cell. 8(6): 973-985. 2. Kelian Xu., Schwarz P,. Luduena R,. (2002) Drug Drug Dev.Re. 55: 91-96. |
Product Images
Chemical structure of Nocodazole (SIH-367), a Microtubule inhibitor. CAS #: 31430-18-9. Molecular Formula: C14H11N3O3S. Molecular Weight: 301.3 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.