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| Product Name | NPC 15437 |
| Description |
PKC kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 141774-20-1 |
| Molecular Formula | C25H52Cl2N4O2 |
| Molecular Weight | 511.6 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in water, DMSO or methanol |
| Source | Synthetic |
| Appearance | White to off-white solid |
| SMILES | O=C(N1C(CNC(=O)[C@@H](N)CCCCN)CCCC1)CCCCCCCCCCCC.Cl.Cl |
| InChI | InChI=1S/C25H50N4O2.2ClH/c1-2-3-4-5-6-7-8-9-10-11-18-24(30)29-20-15-13-16-22(29)21-28-25(31)23(27)17-12-14-19-26;;/h22-23H,2-21,26-27H2,1H3,(H,28,31);2*1H/t22?,23-;;/m0../s1 |
| InChIKey | RISSBZWRJRRXTD-OLBPYZPGSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | NPC 15437 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-464) |
Biological Description
| Alternative Names | (S)-2,6-diamino-N-{[1'-(1''-oxotridecyl)-2'-piperidinyl]methyl}hexanamide . 2HCl |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 16219723 |
| Scientific Background | NPC 15437 is a selective inhibitor of protein kinase C (PKC), acting through interaction with the regulatory domain at residues 12–42. In neuroscience, PKC signaling is involved in synaptic plasticity, memory formation, and neuroinflammation. NPC 15437 is used to study the role of PKC in neuronal signaling and to explore its contribution to neurodegenerative processes. By modulating PKC activity, NPC 15437 helps elucidate the molecular mechanisms underlying synaptic dysfunction and neurodegeneration in diseases such as Alzheimer’s and multiple sclerosis. |
| References |
1. Sullivan J.P., Connor J.R., Shearer B.G., & Burch R.M. (1991) Agents and Actions. 34(1-2): 142–144. 2. Sullivan J.P., Connor J.R., Tiffany C., Shearer B.G., & Burch R.M. (1991) FEBS Letters. 285(1): 120–123. |
Product Images
Chemical structure of NPC 15437 (SIH-464), a PKC kinase inhibitor. CAS #: 141774-20-1. Molecular Formula: C25H52Cl2N4O2. Molecular Weight: 511.6 g/mol.
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