NSC-66811

p53/mdm2 inhibitor

Catalog No. SIH-338

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CAS No. 6964-62-1
Molecular Formula C23H20N2O
SKU: SIH-338 Categories: ,

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SIH-338_NSC-66811_Chemical_Structure.png
Product Name NSC-66811
Description

p53/mdm2 inhibitor

Purity >98%
CAS No. 6964-62-1
Molecular Formula C23H20N2O
Molecular Weight 340.4
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 25 mg/ml DMSO
Source Synthetic
Appearance White Solid
SMILES CC1=NC2=C(C=C1)C=CC(=C2O)C(C3=CC=CC=C3)NC4=CC=CC=C4
InChI InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3
InChIKey WEENRMPCSWFMTE-UHFFFAOYSA-N
Safety Phrases Classification: Caution – Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product NSC-66811 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-338)

Biological Description

Alternative Names 2-Methyl-7-[Phenyl(phenylamino)meth­yl]-8-quinolinol, 7-[Anilino(phenyl)methyl]-2-methylquinolin-8-ol
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, p53/mdm2 Inhibitors
PubChem ID 248986
Scientific Background NSC-66811 is a novel small-molecule inhibitor that disrupts the MDM2-p53 interaction, a key regulatory axis in cell cycle control and apoptosis. By mimicking three critical p53 residues, NSC-66811 binds to MDM2 with high affinity (Ki = 120 nM), preventing MDM2-mediated degradation of p53. This leads to stabilization and activation of p53, promoting transcription of downstream genes involved in cell cycle arrest and apoptosis. While primarily studied in oncology, the p53 pathway is increasingly recognized for its role in neurodegenerative diseases, including Alzheimer's and Parkinson's, where dysregulated apoptosis and impaired DNA repair contribute to neuronal loss. NSC-66811 may offer a mechanistic tool to explore p53-mediated neuroprotection and cellular stress responses in neural models.
References 1. Lu Y., et al. (2006) J. Med.Chem. 49: 3759.

Product Images

<p>Chemical structure of NSC-66811 (SIH-338), a p53/mdm2 inhibitor. CAS #: 6964-62-1. Molecular Formula: C23H20N2O. Molecular Weight: 340.4 g/mol.</p>

Chemical structure of NSC-66811 (SIH-338), a p53/mdm2 inhibitor. CAS #: 6964-62-1. Molecular Formula: C23H20N2O. Molecular Weight: 340.4 g/mol.

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