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| Product Name | NSC59984 |
| Description |
p53-MDM2 inhibitor |
| Purity | >98% |
| CAS No. | 803647-40-7 |
| Molecular Formula | C12H15N3O4 |
| Molecular Weight | 265.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (5 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow to brown powder |
| SMILES | CN1CCN(CC1)C(=O)C=CC2=CC=C(O2)[N+](=O)[O-] |
| InChI | 1S/C12H15N3O4/c1-13-6-8-14(9-7-13)11(16)4-2-10-3-5-12(19-10)15(17)18/h2-5H,6-9H2,1H3/b4-2+ |
| InChIKey | QKTRIGNWBRHBFV-DUXPYHPUSA-N |
| Safety Phrases |
Classification: D2B Toxic Material Causing Other Toxic Effects - Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant Hazard statement(s): H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s): P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of water. P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | NSC59984 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-542) |
Biological Description
| Alternative Names | NSC59984, NSC-59984, NSC59984, MLS000737358, SMR000528276, (E)-1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one, 803647-40-7, AC1NS9AU, CID 5356520, MLS000737358, 1-Methyl-4-[3-(5-nitro-2-furanyl)-1-oxo-2-propenyl]-piperazine, 1-(4-Methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-2-propen-1-one |
| Research Areas | Cancer, Cancer Growth Inhibitors, p53/mdm2 Inhibitors |
| PubChem ID | 5356520 |
| Scientific Background | NSC59984 is a small molecule that restores wild-type p53 signaling in tumor cells by modulating the mutant p53/MDM2 pathway. Although its primary application is in oncology, the compound's ability to influence p53-mediated apoptosis and DNA repair pathways may have relevance in neurodegenerative disease models, where p53 dysregulation contributes to neuronal loss. Its selective cytotoxicity in cancer cells while sparing healthy cells also highlights its potential for targeted therapeutic development. |
Product Images
Chemical structure of NSC59984 (SIH-542), a p53-MDM2 inhibitor. CAS #: 803647-40-7. Molecular Formula: C12H15N3O4. Molecular Weight: 265.3 g/mol.
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