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| Product Name | NVPBEZ235 |
| Description |
PI 3-kinase inhibitor |
| Purity | >97% |
| CAS No. | 915019-65-7 |
| Molecular Formula | C30H23N5O |
| Molecular Weight | 469.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in chloroform (1 mg/ml), 1-methyl-2-pyrrolidnone (2 mg/ml at 75 °C), DMSO (1.33 mg/ml), and DMF (10 mg/ml at 75 °C) |
| Source | Synthetic |
| Appearance | Crystalline solid |
| SMILES | CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5 |
| InChI | InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3 |
| InChIKey | JOGKUKXHTYWRGZ-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Skin irritation (Category 2) Eye irritation (Category 2) Respiratory tract irritation (Category 3) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302+H312 Harmful if swallowed or in contact with skin. H315 Causes skin irritation. H319 Causes serious eye irritation. H332 Harmful if inhaled. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash hands thoroughly after handling. P301+P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302+P352 IF ON SKIN: Wash with plenty of soap and water. P304+P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P332+P313 If skin irritation occurs: Get medical advice/attention. P337+P313 If eye irritation persists: Get medical advice/attention. P363 Wash contaminated clothing before reuse. P501 Dispose of contents/container to an approved waste disposal plant. |
| Cite This Product | NVPBEZ235 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-465) |
Biological Description
| Alternative Names | 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-benzeneacetonitrile |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 11977753 |
| Scientific Background | NVPBEZ235 is a dual inhibitor of PI3K and mTOR, with additional activity against ATR. This compound is widely used in neuroscience to investigate the PI3K/Akt/mTOR signaling pathway, which regulates neuronal survival, metabolism, and autophagy. Dysregulation of this pathway is implicated in neurodegenerative diseases, including Alzheimer’s and Parkinson’s. NVPBEZ235 is employed to study the effects of pathway inhibition on protein aggregation, synaptic function, and neuroinflammation, offering insights into potential therapeutic strategies targeting cellular stress responses in the brain. |
| References |
1. Yasumizu Y., et al. (2014) J. Urology. 191(1): 227–234. 2. Shortt J., et al. (2013) Blood. 121(15): 2964–2974. |
Product Images
Chemical structure of NVPBEZ235 (SIH-465), a PI 3-kinase inhibitor. CAS #: 915019-65-7. Molecular Formula: C30H23N5O. Molecular Weight: 469.5 g/mol.
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