Pazopanib

Tyrosine kinase inhibitor

Catalog No. SIH-506

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CAS No. 444731-52-6
Molecular Formula C21H23N7O2S
SKU: SIH-506 Categories: ,

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SIH-506_Pazopanib_Chemical_Structure.png
Product Name Pazopanib
Description

Tyrosine kinase inhibitor

Purity >98%
CAS No. 444731-52-6
Molecular Formula C21H23N7O2S
Molecular Weight 437.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO, not in water
Source Synthetic
Appearance White solid powder
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
InChI InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
InChIKey CUIHSIWYWATEQL-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Pazopanib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-506)

Biological Description

Alternative Names 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 10113978
Scientific Background Pazopanib is a multi-targeted tyrosine kinase inhibitor primarily used in oncology to inhibit angiogenesis via the HGF/c-MET and VEGF pathways. While its direct application in neuroscience is limited, its anti-angiogenic and anti-inflammatory properties may offer therapeutic potential in neuro-oncology and neuroinflammatory conditions. Ongoing research is exploring its role in modulating the tumor microenvironment in brain cancers such as glioblastoma.
References 1. Outani H., et al. (2014) BMC Cancer. 14: 455.
2. Pick A.M., & Nystrom K.K. (2012) Clin. Ther. 34(3): 511–520.

Product Images

<p>Chemical structure of Pazopanib (SIH-506), a Multi target receptor tyrosine kinase inhibitor. CAS #: 44473-52-6. Molecular Formula: C21H23N7O2S. Molecular Weight: 437.5 g/mol.</p>

Chemical structure of Pazopanib (SIH-506), a Multi target receptor tyrosine kinase inhibitor. CAS #: 44473-52-6. Molecular Formula: C21H23N7O2S. Molecular Weight: 437.5 g/mol.

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