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| Product Name | PD98059 |
| Description |
MEK kinase inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 167869-21-8 |
| Molecular Formula | C16H13NO3 |
| Molecular Weight | 267.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (6mg/mL) |
| Source | Synthetic |
| Appearance | Pale yellow solid |
| SMILES | COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2 |
| InChI | InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3 |
| InChIKey | QFWCYNPOPKQOKV-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 3), H301 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | PD98059 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-466) |
Biological Description
| Alternative Names | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059 |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 4713 |
| Scientific Background | PD98059 is a potent, selective and reversible inhibitor of mitogen-activated protein kinase kinase (MAPKK/ MEK-1) activation. Specifically, it binds to the inactive form of MAPKK, blocking its activation, causing inhibition of phosphorylation and the activation of MAP kinase. It has been shown to enhance self-renewal of embryonic stem cells. PD98059 is cell permeable inhibitor. |
| References |
1. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., & Saltiel A.R. (1995) J. Biol. Chem. 270(46): 27489–27494. 2. Qi X., et al. (2004) Pro. Nat. Acad. Sci. USA. 101(16): 6027–6032. 3. Dudley D.T., Pang L., Decker S.J., Bridges A.J., & Saltiel A.R. (1995) Pro. Nat. Acad. Sci. USA. 92(17): 7686–7689. |
Product Images
Chemical structure of PD98059 (SIH-466), a MEK kinase inhibitor. CAS #: 167869-21-8. Molecular Formula: C16H13NO3. Molecular Weight: 267.3 g/mol.
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