PD98059

MEK kinase inhibitor

Catalog No. SIH-466

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CAS No. 167869-21-8
Molecular Formula C16H13NO3
SKU: SIH-466 Categories: ,

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SIH-466_PD_98059_Chemical_Structure.png
Product Name PD98059
Description

MEK kinase inhibitor

Purity >98% (HPLC); NMR (conforms)
CAS No. 167869-21-8
Molecular Formula C16H13NO3
Molecular Weight 267.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (6mg/mL)
Source Synthetic
Appearance Pale yellow solid
SMILES COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2
InChI InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChIKey QFWCYNPOPKQOKV-UHFFFAOYSA-N
Safety Phrases Classification:
Acute toxicity, Oral (Category 3), H301

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H301 Toxic if swallowed.

Precautionary statements:
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
P321 Specific treatment (see supplemental first aid instructions on this label).
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product PD98059 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-466)

Biological Description

Alternative Names 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 4713
Scientific Background PD98059 is a potent, selective, and reversible inhibitor of MEK1, a kinase upstream of ERK in the MAPK signaling cascade. It binds to the inactive form of MEK1, preventing its activation and subsequent phosphorylation of ERK. In neurodegenerative disease research, PD98059 is used to study the role of MAPK/ERK signaling in neuronal survival, synaptic plasticity, and memory. It is also employed to investigate the impact of ERK inhibition on neuroinflammation and oxidative stress, making it a valuable tool in models of Alzheimer’s and Parkinson’s disease.
References 1. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., & Saltiel A.R. (1995) J. Biol. Chem. 270(46): 27489–27494.
2. Qi X., et al. (2004) Pro. Nat. Acad. Sci. USA. 101(16): 6027–6032.
3. Dudley D.T., Pang L., Decker S.J., Bridges A.J., & Saltiel A.R. (1995) Pro. Nat. Acad. Sci. USA. 92(17): 7686–7689.

Product Images

<p>Chemical structure of PD98059 (SIH-466), a MEK kinase inhibitor. CAS #: 167869-21-8. Molecular Formula: C16H13NO3. Molecular Weight: 267.3 g/mol.</p>

Chemical structure of PD98059 (SIH-466), a MEK kinase inhibitor. CAS #: 167869-21-8. Molecular Formula: C16H13NO3. Molecular Weight: 267.3 g/mol.

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