PHA-665752

MET kinase inhibitor

Catalog No. SIH-421

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CAS No. 477575-56-7
Molecular Formula C32H34Cl2N4O4S
SKU: SIH-421 Categories: ,

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SIH-421_PHA_665752_Chemical_Structure.png
Product Name PHA-665752
Description

MET kinase inhibitor

Purity >98%
CAS No. 477575-56-7
Molecular Formula C32H34Cl2N4O4S
Molecular Weight 641.61
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO.
Source Synthetic
Appearance Yellow solid
SMILES ClC1=C(C(=CC=C1)Cl)C[S](=O)(=O)C3=CC=C2NC(C(/C2=C3)=CC4=C(C(=C([NH]4)C)C(=O)N5CCC[C@@H]5CN6CCCC6)C)=O
InChI InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,1
InChIKey OYONTEXKYJZFHA-SSHUPFPWSA-N
Safety Phrases Classification: Not WHMIS controlled.
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product PHA 665752 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-421)

Biological Description

Alternative Names (2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 10461815
Scientific Background PHA 665752 is a selective inhibitor of the c-Met receptor tyrosine kinase, which is involved in cell growth, survival, and motility. In neuroscience, c-Met signaling plays a role in neurodevelopment, synaptic plasticity, and response to injury. PHA 665752 is used to investigate the impact of c-Met inhibition on neuronal regeneration and neuroinflammation. Dysregulation of c-Met pathways has been implicated in neurodegenerative diseases and brain tumors. By modulating receptor activity, PHA 665752 contributes to understanding the molecular mechanisms of neural repair and disease progression.
References 1. Puri N., Khramtsov A., Ahmed S., Nallasura V., Hetzel J., Jagadeeswaran R., et al. (2007) Cancer Res. 3529-34.

Product Images

<p>Chemical structure of PHA 665752 (SIH-421), a MET kinase inhibitor. CAS #: 477575-56-7. Molecular Formula: C32H34Cl2N4O4S. Molecular Weight: 641.61 g/mol.</p>

Chemical structure of PHA 665752 (SIH-421), a MET kinase inhibitor. CAS #: 477575-56-7. Molecular Formula: C32H34Cl2N4O4S. Molecular Weight: 641.61 g/mol.

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