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| Product Name | PJ-34 |
| Description |
PARP inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 344458-15-7 |
| Molecular Formula | C17H17N3O2•HCL•H2O |
| Molecular Weight | 331.8 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (30 mg/ml) or water (20 mg/ml) |
| Source | Synthetic |
| Appearance | White to yellow solid. |
| SMILES | CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl |
| InChI | InChI=1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22) |
| InChIKey | UYJZZVDLGDDTCL-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | PJ-34 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-366) |
Biological Description
| Alternative Names | N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,Ndimethylacetamide . HCl |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, PARP Inhibitors |
| PubChem ID | 4858 |
| Scientific Background | PJ-34 is a potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell death pathways. In neuroscience, PJ-34 is used to study neuroprotection in models of ischemia, traumatic brain injury, and neurodegeneration. PARP overactivation leads to energy depletion and neuronal death, and PJ-34 mitigates this by preserving cellular NAD⁺ levels. Its anti-inflammatory and anti-apoptotic effects make it a valuable compound for exploring therapeutic strategies aimed at reducing neuronal damage and promoting recovery in neurodegenerative conditions. |
| References | 1. Scott G., Kean R., Mikheeva., Fabis M., Mabley J.J. (2004) The Journal of Pharmacology and Exp. Therapeutics. 310(3): 1053-1061. |
Product Images
Chemical structure of PJ-34 (SIH-366), a PARP inhibitor. CAS #: 344458-15-7. Molecular Formula: C17H17N3O2 *HCL * H2O. Molecular Weight: 331.8 g/mol.
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