PJ-34

PARP inhibitor

Catalog No. SIH-366

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CAS No. 344458-15-7
Molecular Formula C17H17N3O2•HCL•H2O
SKU: SIH-366 Categories: ,

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SIH-366_PJ-34_Chemical_Structure.png
Product Name PJ-34
Description

PARP inhibitor

Purity >98% (HPLC); NMR (conforms)
CAS No. 344458-15-7
Molecular Formula C17H17N3O2•HCL•H2O
Molecular Weight 331.8
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (30 mg/ml) or water (20 mg/ml)
Source Synthetic
Appearance White to yellow solid.
SMILES CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl
InChI InChI=1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22)
InChIKey UYJZZVDLGDDTCL-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product PJ-34 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-366)

Biological Description

Alternative Names N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,Ndimethylacetamide . HCl
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, PARP Inhibitors
PubChem ID 4858
Scientific Background PJ-34 is a potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell death pathways. In neuroscience, PJ-34 is used to study neuroprotection in models of ischemia, traumatic brain injury, and neurodegeneration. PARP overactivation leads to energy depletion and neuronal death, and PJ-34 mitigates this by preserving cellular NAD⁺ levels. Its anti-inflammatory and anti-apoptotic effects make it a valuable compound for exploring therapeutic strategies aimed at reducing neuronal damage and promoting recovery in neurodegenerative conditions.
References 1. Scott G., Kean R., Mikheeva., Fabis M., Mabley J.J. (2004) The Journal of Pharmacology and Exp. Therapeutics. 310(3): 1053-1061.

Product Images

<p>Chemical structure of PJ-34 (SIH-366), a PARP inhibitor. CAS #: 344458-15-7. Molecular Formula: C17H17N3O2  *HCL * H2O. Molecular Weight: 331.8 g/mol.</p>

Chemical structure of PJ-34 (SIH-366), a PARP inhibitor. CAS #: 344458-15-7. Molecular Formula: C17H17N3O2 *HCL * H2O. Molecular Weight: 331.8 g/mol.

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