PP1

Src kinase inhibitor

Catalog No. SIH-469

0 out of 5 based on 0 customer ratings
CAS No. 172889-26-8
Molecular Formula C16H19N5
SKU: SIH-469 Categories: ,

Clear
SIH-469_PP1_Chemical_Structure.png
Product Name PP1
Description

Src kinase inhibitor

Purity >98% (TLC)
CAS No. 172889-26-8
Molecular Formula C16H19N5
Molecular Weight 281.4
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol
Source Synthetic
Appearance Tan solid
SMILES CC1=CC=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C(C)(C)C
InChI InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
InChIKey ZVPDNRVYHLRXLX-UHFFFAOYSA-N
Safety Phrases Classification:
Acute toxicity, Oral (Category 3), H301

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H301 Toxic if swallowed.

Precautionary statements:
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
P321 Specific treatment (see supplemental first aid instructions on this label).
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product PP1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-469)

Biological Description

Alternative Names 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 1400
Scientific Background PP1 is a potent and selective inhibitor of Src family protein tyrosine kinases. It binds to the ATP-binding site of tyrosine and serine/threonine kinases, displaying high selectivity over ZAP-70 and JAK2. In neuroscience, PP1 is used to study the role of Src kinases in synaptic plasticity, neuronal development, and neuroinflammation. It is particularly useful in models of excitotoxicity and neurodegeneration, where Src signaling contributes to calcium dysregulation and cell death.
References 1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701.
2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.

Product Images

<p>Chemical structure of PP1 (SIH-469), a Src family kinase inhibitor. CAS #: 172889-26-8. Molecular Formula: C16H19N5. Molecular Weight: 281.4 g/mol.</p>

Chemical structure of PP1 (SIH-469), a Src family kinase inhibitor. CAS #: 172889-26-8. Molecular Formula: C16H19N5. Molecular Weight: 281.4 g/mol.

Reviews

Reviews

There are no reviews yet.

Be the first to review “PP1”

Your email address will not be published. Required fields are marked *