PP1

Name: PP1
SKU: SIH-469
Availability: InStock

Src kinase inhibitor

Catalog No. SIH-469

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CAS No.	172889-26-8
Molecular Formula	C16H19N5

SKU: SIH-469 Categories: Inhibitor, Small Molecules

Product Name	PP1
Description	Src kinase inhibitor
Purity	>98% (TLC)
CAS No.	172889-26-8
Molecular Formula	C₁₆H₁₉N₅
Molecular Weight	281.4
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol
Source	Synthetic
Appearance	Tan solid
SMILES	CC1=CC=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C(C)(C)C
InChI	InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
InChIKey	ZVPDNRVYHLRXLX-UHFFFAOYSA-N
Safety Phrases	Classification: Acute toxicity, Oral (Category 3), H301 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product	PP1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-469)

Alternative Names	1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID	1400
Scientific Background	PP1 is a potent and selective inhibitor of Src family protein tyrosine kinases. It binds to the ATP-binding site of tyrosine and serine/threonine kinases, displaying high selectivity over ZAP-70 and JAK2. In neuroscience, PP1 is used to study the role of Src kinases in synaptic plasticity, neuronal development, and neuroinflammation. It is particularly useful in models of excitotoxicity and neurodegeneration, where Src signaling contributes to calcium dysregulation and cell death.
References	1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701. 2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.

Chemical structure of PP1 (SIH-469), a Src family kinase inhibitor. CAS #: 172889-26-8. Molecular Formula: C16H19N5. Molecular Weight: 281.4 g/mol.

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