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| Product Name | Puromycin HCl |
| Description |
Translation inhibitor |
| Purity | >98% (TLC, HPLC); NMR (Conforms) |
| CAS No. | 58-58-2 |
| Molecular Formula | C22H29N7O5•2HCl |
| Molecular Weight | 544.43 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (50 mg/ml); or water (50 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O |
| InChI | InChI=1S/C22H29N7O5/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5 |
| InChIKey | RXWNCPJZOCPEPQ-WABMVTPESA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Puromycin HCl (StressMarq Biosciences, Canada, Cat # SIH-248) |
Biological Description
| Alternative Names | 3'-Deoxy-N,N-dimethyl-3'-[(O-methyl-L-tyrosyl)amino]adenosine |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5891 |
| Scientific Background | Puromycin is a broad-spectrum antibiotic and potent inhibitor of protein synthesis. It mimics the 3' end of aminoacyl-tRNA and incorporates into the ribosome's A site, causing premature termination of translation. This mechanism disrupts polypeptide elongation, making puromycin a valuable tool for studying protein synthesis and turnover in both prokaryotic and eukaryotic systems. In neuroscience, puromycin is frequently used to investigate synaptic plasticity, neuronal translation dynamics, and the regulation of local protein synthesis in dendrites and axons—processes critical to memory formation and neurodevelopment. |
| References | 1. Azzam and Algranati. (1973) Proc Natl Acad Sci. 70: 3866. |
Product Images
Chemical structure of Puromycin HCl (SIH-248), a Translation inhibitor. CAS #: 58-58-2. Molecular Formula: C22H29N7O5 x 2HCl. Molecular Weight: 544.43 g/mol.
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Based on validation through cited publications.