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| Product Name | Pyr41 |
| Description |
E1 UAE inhibitor |
| Purity | >98% |
| CAS No. | 418805-02-4 |
| Molecular Formula | C17H13N3O7 |
| Molecular Weight | 371.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 25 mg/ml DMSO |
| Source | Synthetic |
| Appearance | Brown Powder |
| SMILES | CCOC(=O)C1=CC=C(C=C1)N2C(=O)/C(=CC3=CC=C(O3)[N+](=O)[O-])/C(=O)N2 |
| InChI | InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9- |
| InChIKey | ARGIPZKQJGFSGQ-LCYFTJDESA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302 – May be harmful if swallowed H317 – May cause an allergic skin reaction Precautionary Statements: P280 – Wear protective gloves |
| Cite This Product | Pyr41 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-330) |
Biological Description
| Alternative Names | Ethyl 4-{(4Z)-4-[(5-nitro-2-furyl)methylene]-3,5-dioxo-1-pyrazolidinyl}benzoate, PYR-41, 4[4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5335621 |
| Scientific Background | Inhibits ubiquitin activating enzyme E1 (>60% inhibition at 10 µM) with little or no activity against E2 or E3. Cell permeable. |
| References |
1. Yang Y., et al. (2007) Cancer Res. 67: 9472. 2. Mi L., et al. (2009) J. Biol. Chem. 284: 17039. |
Product Images
Chemical structure of Pyr41 (SIH-330), a E1 UAE inhibitor. CAS #: 418805-02-4. Molecular Formula: C17H13N3O7 . Molecular Weight: 371.3 g/mol.
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