Pyr-41

Ubiquitin-Activating Enzyme (E1) Inhibitor

Catalog No. SIH-330

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CAS No. 418805-02-4
Molecular Formula C17H13N3O7
SKU: SIH-330 Categories: ,

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SIH-330_Pyr41_Chemical_Structure.png
Product Name Pyr-41
Description

Ubiquitin-Activating Enzyme (E1) Inhibitor

Purity >98%
CAS No. 418805-02-4
Molecular Formula C17H13N3O7
Molecular Weight 371.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 25 mg/ml DMSO
Source Synthetic
Appearance Brown Powder
SMILES CCOC(=O)C1=CC=C(C=C1)N2C(=O)/C(=CC3=CC=C(O3)[N+](=O)[O-])/C(=O)N2
InChI InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-
InChIKey ARGIPZKQJGFSGQ-LCYFTJDESA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H302 – May be harmful if swallowed
H317 – May cause an allergic skin reaction
Precautionary Statements:
P280 – Wear protective gloves
Cite This Product Pyr41 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-330)

Biological Description

Alternative Names Ethyl 4-{(4Z)-4-[(5-nitro-2-furyl)methylene]-3,5-dioxo-1-pyrazolidinyl}benzoate, PYR-41, 4[4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester
Research Areas Apoptosis, Cancer
PubChem ID 5335621
Scientific Background Pyr-41 inhibits the ubiquitin-activating enzyme E1, thereby modulating the ubiquitination pathway. It is cell permeable and has been used in neuroscience to investigate the role of ubiquitin signaling in neuronal survival, synaptic function, and neurodegenerative disease mechanisms involving protein turnover and stress responses.
References 1. Yang Y., et al. (2007) Cancer Res. 67: 9472.
2. Mi L., et al. (2009) J. Biol. Chem. 284: 17039.

Product Images

<p>Chemical structure of Pyr41 (SIH-330), a E1 UAE inhibitor. CAS #: 418805-02-4. Molecular Formula: C17H13N3O7 . Molecular Weight: 371.3 g/mol.</p>

Chemical structure of Pyr41 (SIH-330), a E1 UAE inhibitor. CAS #: 418805-02-4. Molecular Formula: C17H13N3O7 . Molecular Weight: 371.3 g/mol.

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