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| Product Name | (R,S)-Niguldipine HCl |
| Description |
Ca2+ channel blocker |
| Purity | >98% |
| CAS No. | 119934-51-9 |
| Molecular Formula | C36H39N3O6•HCl |
| Molecular Weight | 646.18 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 10 mM in water |
| Source | Synthetic |
| Appearance | Yellow solid |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with shin and eyes |
| Cite This Product | (R, S)-Niguldipine HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-319) |
Biological Description
| Alternative Names | (R,S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride |
| Research Areas | Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels |
| Scientific Background | Niguldipine is a calcium channel blocker and alpha1-adrenergic receptor antagonist. In neuroscience, its dual action on calcium influx and adrenergic signaling makes it a candidate for studying neurovascular coupling and synaptic transmission. Its modulation of intracellular calcium dynamics may have implications for neurodegenerative disease models involving calcium dysregulation. |
| References |
1. Boer R., Grassegger A., Schudt C., Glossman H. (1999) Eur J Pharmacol. 172(2): 131-145. 2. Robinson J.P., Kendall D.A. (1990) Br J Pharmacol. 100(1): 3-4. |
Product Images
Chemical structure of (R, S)-Niguldipine HCl (SIH-319), a L-type Ca channel blocker. CAS #: 113317-61-6. Molecular Formula: C36H39N3O6.HCl. Molecular Weight: 646.18 g/mol.
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