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| Product Name | Ro 20-1724 |
| Description |
PDE4 inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 29925-17-5 |
| Molecular Formula | C15H22N2O3 |
| Molecular Weight | 278.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (200 mg/ml) or ethanol (40 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | CCCCOC1=CC(CC2CNC(=O)N2)=CC=C1OC |
| InChI | InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) |
| InChIKey | PDMUULPVBYQBBK-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Ro 20-1724 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-527) |
Biological Description
| Alternative Names | B8279, 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one, Ro 20 1724, RO 20-1724, 4-(3-butoxy-4-methoxy-benzyl)imidazolidin-2-one |
| Research Areas | Cell Signaling |
| PubChem ID | 5087 |
| Scientific Background | Ro 20-1724 is a selective inhibitor of cyclic AMP-specific phosphodiesterase type IV (PDE4). In neuroscience, it is used to elevate intracellular cAMP levels, thereby enhancing memory formation, synaptic plasticity, and neuroprotection. PDE4 inhibitors like Ro 20-1724 have been explored for their therapeutic potential in neurodegenerative diseases, including Alzheimer's and Huntington's disease, due to their ability to modulate inflammatory responses and support neuronal survival. Its role in cAMP signaling makes it a valuable compound for studying second messenger systems in the brain. |
Product Images
Chemical structure of Ro 20-1724 (SIH-527), a PDE4 inhibitor. CAS #: 29925-17-5. Molecular Formula: C15H22N2O3. Molecular Weight: 278.3 g/mol.
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