Rolipram

Autophagy inhibitor

Catalog No. SIH-401

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CAS No. 61413-54-5
Molecular Formula C16H21NO3
SKU: SIH-401 Categories: ,

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SIH-401_Rolipram_Chemical_Structure.png
Product Name Rolipram
Description

Autophagy inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 61413-54-5
Molecular Formula C16H21NO3
Molecular Weight 275.35
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 75 mM in DMSO and to 75 mM in ethanol.
Source Synthetic
Appearance White to off-white solid.
SMILES C1=C(C(=CC=C1C2CNC(C2)=O)OC)OC3CCCC3
InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
InChIKey HJORMJIFDVBMOB-UHFFFAOYSA-N
Safety Phrases Classification: D2B- Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315- Causes skin irritation.
H319- Causes serious eye irritation.
H335- May cause respiratory irritation.
Precautionary statements:
P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264- Wash skin thoroughly after handling.
P271- Use only outdoors or in a well-ventilated area.
P280- Wear protective gloves/ eye protection/ face protection.
P302 + P352- IF ON SKIN: Wash with plenty of soap and water.
P304 + P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312- Call a POISON CENTER or doctor/ physician if you feel unwell.
P321- Specific treatment (see supplemental first aid instructions on this label).
P332 + P313- If skin irritation occurs: Get medical advice/ attention.
P337 + P313- If eye irritation persists: Get medical advice/ attention.
P362- Take off contaminated clothing and wash before reuse.
P403 + P233- Store in a well-ventilated place. Keep container tightly closed.
P405- Store locked up.
P501- Dispose of contents/ container to an approved waste disposal plant.
Cite This Product Rolipram (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-401)

Biological Description

Alternative Names 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
Research Areas Autophagy, Cancer
PubChem ID 5092
Scientific Background Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor that elevates intracellular cAMP levels, thereby modulating signaling pathways involved in inflammation, neuroplasticity, and cell survival. In neuroscience, Rolipram has been extensively studied for its neuroprotective and cognitive-enhancing effects. By increasing cAMP, Rolipram enhances the activity of protein kinase A (PKA) and the transcription factor CREB, which are critical for memory formation and synaptic plasticity. It also reduces the production of pro-inflammatory cytokines, making it a promising candidate for mitigating neuroinflammation in neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Rolipram has shown efficacy in preclinical models of depression, traumatic brain injury, and multiple sclerosis, highlighting its broad therapeutic potential in CNS disorders.
References 1. Kato H., et al. (1995) Eur J Pharmacol. 272(1): 107-10.
2. Christian F., et al. (2010) Cell Signal. 22(10): 1576-96.
3. Houslay M.D., & Christian F. (2010) Autophagy. 6(8): 1198-200.

Product Images

<p>Chemical structure of Rolipram (SIH-401), a Autophagy inhibitor. CAS #: 61413-54-5 . Molecular Formula: C16H21NO3. Molecular Weight: 275.35 g/mol.</p>

Chemical structure of Rolipram (SIH-401), a Autophagy inhibitor. CAS #: 61413-54-5 . Molecular Formula: C16H21NO3. Molecular Weight: 275.35 g/mol.

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