Ruxolitinib

JAK kinase inhibitor

Catalog No. SIH-509

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CAS No. 941678-49-5
Molecular Formula C17H18N6
SKU: SIH-509 Categories: ,

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SIH-509_Ruxolitinib_Chemical_Structure.png
Product Name Ruxolitinib
Description

JAK kinase inhibitor

Purity >98%
CAS No. 941678-49-5
Molecular Formula C17H18N6
Molecular Weight 306.4
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (25 mg/ml) or EtOH (~15 mg/ml)
Source Synthetic
Appearance Off-white solid
SMILES C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
InChI InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1
InChIKey HFNKQEVNSGCOJV-OAHLLOKOSA-N
Safety Phrases Classification:
Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 1 Danger
Target Organ Systemic Toxicity (repeated exposure), Category 2
Toxic To Reproduction, Category 2 Warning
Acute Toxicity: Oral, Category 4

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H315: Causes skin irritation.
H318: Causes serious eye damage
H373: May cause damage to organs through prolonged or repeated exposure.
H361: Suspected of damaging fertility or the unborn child.
H302: Harmful if swallowed.

Precautionary statements:
P264: Wash hands thoroughly after handling.
P280: Wear protective gloves/clothing and eye/face protection as specified by the
manufacturer/supplier or the competent authority.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P332+313: If skin irritation occurs, get medical advice/attention.
P362: Take off contaminated clothing and wash before re-use.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P310: Immediately call a POISON CENTER or doctor/physician.
P314: Get medical attentiodvice if you feel unwell.
P308+313: IF exposed or concerned: Get medical attentiodvice.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P330: Rinse mouth.
Cite This Product Ruxolitinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-509)

Biological Description

Alternative Names (3R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 25126798
Scientific Background Ruxolitinib is a selective inhibitor of Janus-associated kinases (JAK1 and JAK2), key mediators in cytokine signaling pathways. While primarily developed for hematologic malignancies and inflammatory disorders, Ruxolitinib has gained attention in neurodegenerative disease research due to its ability to modulate neuroinflammation. Dysregulated JAK/STAT signaling is implicated in several neurodegenerative conditions, including Alzheimer's and Parkinson's disease. By suppressing pro-inflammatory cytokine signaling, Ruxolitinib may reduce microglial activation and neuronal damage. Its potential to cross the blood-brain barrier further supports its exploration as a neuroprotective agent.
References 1. Aittomäki S., & Pesu M. (2014) Basic & Clin. Pharm.Toxic. 114(1): 18–23.

Product Images

<p>Chemical structure of Ruxolitinib (SIH-509), a JAK kinase inhibitor. CAS #: 941678-49-5. Molecular Formula: C17H18N6. Molecular Weight: 306.4 g/mol.</p>

Chemical structure of Ruxolitinib (SIH-509), a JAK kinase inhibitor. CAS #: 941678-49-5. Molecular Formula: C17H18N6. Molecular Weight: 306.4 g/mol.

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