Santacruzamate A

Ultrapotent HDAC2 inhibitor

Catalog No. SIH-613

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CAS No. 1477949-42-0
Molecular Formula C15H22N2O3
SKU: SIH-613 Categories: ,

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SIH-613-Santacruzamate-A-Chemical-Structure.png
Product Name Santacruzamate A
Description

Ultrapotent HDAC2 inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 1477949-42-0
Molecular Formula C15H22N2O3
Molecular Weight 278.4
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (25 mg/ml); or Ethanol (20 mg/ml)
Source Synthetic
Appearance Off-white powder
SMILES O=C(CCCNC(OCC)=O)NCCC1=CC=CC=C1, O=C(CCCNC(OCC)=O)NCCC1=CC=CC=C2, O=C(CCCNC(OCC)=O)NCCC1=CC=CC=C3
InChI InChI=1S/C15H22N2O3/c1-2-20-15(19)17-11-6-9-14(18)16-12-10-13-7-4-3-5-8-13/h3-5,7-8H,2,6,9-12H2,1H3,(H,16,18)(H,17,19) 
InChIKey HTOYBIILVCHURC-UHFFFAOYSA-N  
Safety Phrases GHS Hazard Statements: Not Classified
Cite This Product Santacruzamate A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-613)

Biological Description

Alternative Names N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester
Research Areas Alzheimer's Disease, Apoptosis, Cancer, Neurodegeneration, Neuroscience
PubChem ID 72946782
Scientific Background Santacruzamate A is a highly selective histone deacetylase 2 (HDAC2) inhibitor derived from marine cyanobacteria. It has been studied for its neuroprotective effects in Alzheimer’s disease models, where it attenuates amyloid-beta-induced toxicity and enhances endoplasmic reticulum stress tolerance. Its selectivity for HDAC2 over HDAC6 makes it a promising candidate for epigenetic modulation in neurodegenerative disease therapy, with potential applications in memory enhancement and synaptic plasticity.
References 1. Pavlik C.M., et al. (2013) J. Nat. Prod. 76:2026
2.Zhou et al. H., (2018) Cell Prolif. 51(3):e12477
3. Damaskos C., et al. (2017) Anticancer Res. 37:35
4.Chen L., et al. (2019) Front. Cell. Neurosci. 13:61

Product Images

<p>Chemical structure of Santacruzamate A (SIH-613), a Ultrapotent HDAC2 inhibitor. CAS #: 1477949-42-0. Molecular Formula: C15H22N2O3. Molecular Weight: 278.4 g/mol.</p>

Chemical structure of Santacruzamate A (SIH-613), a Ultrapotent HDAC2 inhibitor. CAS #: 1477949-42-0. Molecular Formula: C15H22N2O3. Molecular Weight: 278.4 g/mol.

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