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| Product Name | SB202190 |
| Description |
p38 MAP kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 152121-30-7 |
| Molecular Formula | C20H14FN3O |
| Molecular Weight | 331.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate |
| Source | Synthetic |
| Appearance | Pale yellow solid |
| SMILES | C4=C(C1=C(NC(N1)=C2C=CC(=O)C=C2)C3=CC=NC=C3)C=CC(=C4)F |
| InChI | InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H |
| InChIKey | NJNKPVPFGLGHPA-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well - ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instru ctions on this label). P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant |
| Cite This Product | SB202190 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-473) |
Biological Description
| Alternative Names | FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 5353940 |
| Scientific Background | SB202190 is a highly selective and potent inhibitor of p38 MAP kinase, specifically targeting the p38α and p38β isoforms. It binds within the ATP-binding pocket of the active kinase, preventing phosphorylation events that drive inflammatory and stress-related signaling. In neurodegenerative disease research, SB202190 is used to investigate the role of p38 MAPK in neuronal apoptosis, synaptic dysfunction, and neuroinflammation. Its ability to induce apoptosis and modulate stress-activated pathways makes it a valuable tool for studying mechanisms underlying Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions. SB202190 is cell-permeable and widely used in both in vitro and in vivo models to explore kinase-targeted neuroprotective strategies. |
| References |
1. Nemoto S., Xiang J., Huang S., & Lin A. (1998) J. Bio. Chem. 273(26): 16415–16420. 2. Karahashi H., Nagata K., Ishii K., & Amano F. (2000) Biochimica Et Biophysica Acta. 1502(2): 207–223. |
Product Images
Chemical structure of SB202190 (SIH-473), a p38 MAP kinase inhibitor. CAS #: 152121-30-7. Molecular Formula: C20H14FN3O. Molecular Weight: 331.3 g/mol.
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