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| Product Name | SB203580 |
| Description |
p38 MAP kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 152121-47-6 |
| Molecular Formula | C21H16FN3OS |
| Molecular Weight | 377.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (50 mg/ml) |
| Source | Synthetic |
| Appearance | White to off-white powder |
| SMILES | C1=C(C=CC(=C1)C2=C([NH]C(=N2)C3=CC=C(C=C3)[S](C)=O)C4=CC=NC=C4)F |
| InChI | InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) |
| InChIKey | CDMGBJANTYXAIV-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 4), H302 Serious eye damage (Category 1), H318 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H318 Causes serious eye damage. Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/ eye protection/ face protection. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P305 + P351 + P338 IF IN EYES: Rinse cautiously wit h water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER or doctor/ physician. P330 Rinse mouth. P501 Dispose of contents/ container to an approved waste disposal plant |
| Cite This Product | SB203580 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-474) |
Biological Description
| Alternative Names | 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 176155 |
| Scientific Background | SB203580 is a pyridinyl imidazole compound that selectively inhibits p38 MAP kinase, particularly the p38α isoform. It also inhibits phosphorylation of heat shock protein 27 (HSP27) and can activate Raf-1 signaling. In neuroscience, SB203580 is used to study the role of p38 MAPK in neuroinflammation, synaptic plasticity, and neuronal survival. Its high selectivity over kinases such as LCK, GSK-3β, and PKBα makes it a reliable tool for dissecting p38-mediated signaling in neurodegenerative disease models. SB203580 is cell-permeable and is frequently employed in studies of Alzheimer's disease, stroke, and other CNS disorders involving inflammatory and stress responses. |
| References |
1. Hall-Jackson C. A., Goedert M., Hedge P., & Cohen P. (1999) Oncogene. 18(12): 2047–2054. 2. Saklatvala, J., et al. (1996) J. Bio. Chem. 271(12): 6586–6589. 3. Cuenda A., et al. (1995) FEBS Letters. 364(2): 229–233. |
Product Images
Chemical structure of SB203580 (SIH-474), a p38 MAP kinase inhibitor. CAS #: 152121-47-6. Molecular Formula: C21H16FN3OS. Molecular Weight: 377.4 g/mol.
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