Sirtinol

SIRT inhibitor

Catalog No. SIH-360

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CAS No. 410536-97-9
Molecular Formula C26H22N2O2
SKU: SIH-360 Categories: ,

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SIH-360_Sirtinol_Chemical_Structure.png
Product Name Sirtinol
Description

SIRT inhibitor

Purity >98%
CAS No. 410536-97-9
Molecular Formula C26H22N2O2
Molecular Weight 394.47
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO
Source Synthetic
Appearance Off-white to yellow crystals
SMILES [C@@H](NC(=O)C1=CC=CC=C1NC=C/3C2=CC=CC=C2C=CC3=O)(C4=CC=CC=C4)C
InChI InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,27H,1H3,(H,28,30)/b23-17-
InChIKey YUGODMKHHCZZOI-QJOMJCCJSA-N
Safety Phrases Classification: Caution. Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product Sirtinol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-360)

Biological Description

Alternative Names 2-[[(2-Hydroxy-1-naphthalenyl)methy­lene]amino]-N-(1-phenylethyl)benzamide
Research Areas Cell Signaling
PubChem ID 5717148
Scientific Background Sirtinol is a selective, cell-permeable inhibitor of sirtuin deacetylases (IC50: 38 µM for SIRT2, 68 µM for Sir2p, 131 µM for SIRT1), with no effect on HDAC1. Sirtuins are key regulators of aging, stress response, and neurodegeneration.

Sirtinol’s specificity enables precise investigation of sirtuin-mediated pathways in neuronal survival, synaptic plasticity, and neuroinflammation. Its relevance in Alzheimer’s and Parkinson’s research is growing, as sirtuin-targeted therapies gain traction. Sirtinol is widely used in neuroscience to explore epigenetic mechanisms underlying cognitive decline and neuronal resilience.
References 1. Grozinger CM., et al (2001) J.Biol.Chem. 276: 38837.
2. Mai A., et al (2005) J.Med.Chem. 48: 7789.
3. Kahyo T., et al (2008) J.Pharmacol.Sci. 108: 364.
4. Jung-Hynes B., et al (2009) J.Biol.Chem. 284: 3823.

Product Images

<p>Chemical structure of Sirtinol (SIH-360), a SIRT inhibitor. CAS #: 410536-97-9. Molecular Formula: C26H22N2O2. Molecular Weight: 394.47 g/mol.</p>

Chemical structure of Sirtinol (SIH-360), a SIRT inhibitor. CAS #: 410536-97-9. Molecular Formula: C26H22N2O2. Molecular Weight: 394.47 g/mol.

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