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| Product Name | Sirtinol |
| Description |
SIRT inhibitor |
| Purity | >98% |
| CAS No. | 410536-97-9 |
| Molecular Formula | C26H22N2O2 |
| Molecular Weight | 394.47 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | Off-white to yellow crystals |
| SMILES | [C@@H](NC(=O)C1=CC=CC=C1NC=C/3C2=CC=CC=C2C=CC3=O)(C4=CC=CC=C4)C |
| InChI | InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,27H,1H3,(H,28,30)/b23-17- |
| InChIKey | YUGODMKHHCZZOI-QJOMJCCJSA-N |
| Safety Phrases |
Classification: Caution. Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | Sirtinol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-360) |
Biological Description
| Alternative Names | 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide |
| Research Areas | Cell Signaling |
| PubChem ID | 5717148 |
| Scientific Background | Cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 µM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro. |
| References |
1. Grozinger CM., et al (2001) J.Biol.Chem. 276: 38837. 2. Mai A., et al (2005) J.Med.Chem. 48: 7789. 3. Kahyo T., et al (2008) J.Pharmacol.Sci. 108: 364. 4. Jung-Hynes B., et al (2009) J.Biol.Chem. 284: 3823. |
Product Images
Chemical structure of Sirtinol (SIH-360), a SIRT inhibitor. CAS #: 410536-97-9. Molecular Formula: C26H22N2O2. Molecular Weight: 394.47 g/mol.
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