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| Product Name | SMER3 |
| Description |
E3 UB ligase inhibitor |
| Purity | >98% |
| CAS No. | 67200-34-4 |
| Molecular Formula | C11H4N4O2 |
| Molecular Weight | 224.18 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 75 mM DMSO |
| Source | Synthetic |
| Appearance | Yellow Solid |
| SMILES | C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O |
| InChI | InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H |
| InChIKey | SFSSAKVWCKFRHE-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | SMER3 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-341) |
Biological Description
| Alternative Names | 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 568763 |
| Scientific Background | SMER3 is a small-molecule modulator that selectively inhibits a yeast SCF (Skp1-Cullin-F-box) family E3 ubiquitin ligase. It induces the expression of MET genes and blocks cell proliferation, and has been identified as an enhancer of rapamycin. Although initially characterized in yeast, SMER3's modulation of ubiquitin ligase activity is of interest in neurodegenerative disease research, where dysregulated protein turnover and autophagy are central to pathogenesis. SMER3 may provide insights into E3 ligase function and its therapeutic modulation in neuronal systems. |
| References | 1. Aghajanyy et al. (2010) Nat.Biotechnol. 28: 738. |
Product Images
Chemical structure of SMER3 (SIH-341), a E3 UB ligase inhibitor. CAS #: 67200-34-4. Molecular Formula: C11H4N4O2. Molecular Weight: 224.18 g/mol.
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