SMER3

E3 UB ligase inhibitor

Catalog No. SIH-341

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CAS No. 67200-34-4
Molecular Formula C11H4N4O2
SKU: SIH-341 Categories: ,

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SIH-341_SMER3_Chemical_Structure.png
Product Name SMER3
Description

E3 UB ligase inhibitor

Purity >98%
CAS No. 67200-34-4
Molecular Formula C11H4N4O2
Molecular Weight 224.18
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 75 mM DMSO
Source Synthetic
Appearance Yellow Solid
SMILES C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O
InChI InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H
InChIKey SFSSAKVWCKFRHE-UHFFFAOYSA-N
Safety Phrases Classification: Caution – Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product SMER3 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-341)

Biological Description

Alternative Names 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
Research Areas Apoptosis, Cancer
PubChem ID 568763
Scientific Background SMER3 is a small-molecule modulator that selectively inhibits a yeast SCF (Skp1-Cullin-F-box) family E3 ubiquitin ligase. It induces the expression of MET genes and blocks cell proliferation, and has been identified as an enhancer of rapamycin. Although initially characterized in yeast, SMER3's modulation of ubiquitin ligase activity is of interest in neurodegenerative disease research, where dysregulated protein turnover and autophagy are central to pathogenesis. SMER3 may provide insights into E3 ligase function and its therapeutic modulation in neuronal systems.
References 1. Aghajanyy et al. (2010) Nat.Biotechnol. 28: 738.

Product Images

<p>Chemical structure of SMER3 (SIH-341), a E3 UB ligase inhibitor. CAS #: 67200-34-4. Molecular Formula: C11H4N4O2. Molecular Weight: 224.18 g/mol.</p>

Chemical structure of SMER3 (SIH-341), a E3 UB ligase inhibitor. CAS #: 67200-34-4. Molecular Formula: C11H4N4O2. Molecular Weight: 224.18 g/mol.

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