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| Product Name | SMER3 |
| Description |
E3 UB ligase inhibitor |
| Purity | >98% |
| CAS No. | 67200-34-4 |
| Molecular Formula | C11H4N4O2 |
| Molecular Weight | 224.18 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 75 mM DMSO |
| Source | Synthetic |
| Appearance | Yellow Solid |
| SMILES | C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O |
| InChI | InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H |
| InChIKey | SFSSAKVWCKFRHE-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | SMER3 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-341) |
Biological Description
| Alternative Names | 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 568763 |
| Scientific Background | Specific inhibitor of a yeast SCF family E3 ubiquitin ligase (SCF) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin. |
| References | 1. Aghajanyy et al. (2010) Nat.Biotechnol. 28: 738. |
Product Images
Chemical structure of SMER3 (SIH-341), a E3 UB ligase inhibitor. CAS #: 67200-34-4. Molecular Formula: C11H4N4O2. Molecular Weight: 224.18 g/mol.
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