SMI-4a

ATP-competitive Pim kinase inhibitor

Catalog No. SIH-572

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CAS No. 438190-29-5
Molecular Formula C11H6F3NO2S
SKU: SIH-572 Categories: ,

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SIH-572-SMI-4a-Chemical-Structure.png
Product Name SMI-4a
Description

ATP-competitive Pim kinase inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 438190-29-5
Molecular Formula C11H6F3NO2S
Molecular Weight 273.23
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (100 mg/ml); or Ethanol (40 mg/ml, warm)
Source Synthetic
Appearance Tan solid
SMILES C1=CC(=CC(=C1)C(F)(F)F)C=C2C(=O)NC(=O)S2
InChI InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5-
InChIKey NGJLOFCOEOHFKQ-YVMONPNESA-N
Safety Phrases Hazard statements:
H317 - May cause an allergic skin reaction
H319 - Causes serious eye irritation

Precautionary Statements:
P261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray
P264 - Wash face, hands and any exposed skin thoroughly after handling
P272 - Contaminated work clothing should not be allowed out of the workplace
P280 - Wear protective gloves/ protective clothing/ eye protection/ face protection
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing
P333 + P313 - If skin irritation or rash occurs: Get medical advice/ attention
P337 + P313 - If eye irritation persists: Get medical advice/ attention
P362 - Take off contaminated clothing and wash before reuse
Cite This Product SMI-4a (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-572)

Biological Description

Alternative Names 5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione
Research Areas Apoptosis, Cancer, Cell Signaling, Other Kinases, Protein Phosphorylation
PubChem ID 1361334
Scientific Background SMI-4a is a selective inhibitor of Pim kinases, particularly Pim-1, which are involved in cell survival and proliferation. Although primarily studied in cancer research, SMI-4a is gaining interest in neuroscience for its potential to modulate apoptotic pathways and neuroinflammation. Its ability to influence kinase signaling cascades may offer insights into neuronal survival mechanisms and therapeutic strategies for neurodegenerative diseases.

Product Images

<p>Chemical structure of SMI-4a (SIH-572), a ATP-competitive Pim kinase inhibitor. CAS #: 438190-29-5. Molecular Formula: C11H6F3NO2S. Molecular Weight: 273.23 g/mol.</p>

Chemical structure of SMI-4a (SIH-572), a ATP-competitive Pim kinase inhibitor. CAS #: 438190-29-5. Molecular Formula: C11H6F3NO2S. Molecular Weight: 273.23 g/mol.

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