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| Product Name | SMI-4a |
| Description |
ATP-competitive Pim kinase inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 438190-29-5 |
| Molecular Formula | C11H6F3NO2S |
| Molecular Weight | 273.23 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (100 mg/ml); or Ethanol (40 mg/ml, warm) |
| Source | Synthetic |
| Appearance | Tan solid |
| SMILES | C1=CC(=CC(=C1)C(F)(F)F)C=C2C(=O)NC(=O)S2 |
| InChI | InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5- |
| InChIKey | NGJLOFCOEOHFKQ-YVMONPNESA-N |
| Safety Phrases |
Hazard statements: H317 - May cause an allergic skin reaction H319 - Causes serious eye irritation Precautionary Statements: P261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray P264 - Wash face, hands and any exposed skin thoroughly after handling P272 - Contaminated work clothing should not be allowed out of the workplace P280 - Wear protective gloves/ protective clothing/ eye protection/ face protection P302 + P352 - IF ON SKIN: Wash with plenty of soap and water P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P333 + P313 - If skin irritation or rash occurs: Get medical advice/ attention P337 + P313 - If eye irritation persists: Get medical advice/ attention P362 - Take off contaminated clothing and wash before reuse |
| Cite This Product | SMI-4a (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-572) |
Biological Description
| Alternative Names | 5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione |
| Research Areas | Apoptosis, Cancer, Cell Signaling, Other Kinases, Protein Phosphorylation |
| PubChem ID | 1361334 |
| Scientific Background | SMI-4a is a selective inhibitor of Pim kinases, particularly Pim-1, which are involved in cell survival and proliferation. Although primarily studied in cancer research, SMI-4a is gaining interest in neuroscience for its potential to modulate apoptotic pathways and neuroinflammation. Its ability to influence kinase signaling cascades may offer insights into neuronal survival mechanisms and therapeutic strategies for neurodegenerative diseases. |
Product Images
Chemical structure of SMI-4a (SIH-572), a ATP-competitive Pim kinase inhibitor. CAS #: 438190-29-5. Molecular Formula: C11H6F3NO2S. Molecular Weight: 273.23 g/mol.
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