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| Product Name | Sodium Valproate |
| Description |
HDAC inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 1069-66-5 |
| Molecular Formula | C8H15NaO2 |
| Molecular Weight | 166.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 50 mg/ml Water |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | CCCC(CCC)C(=O)[O-].[Na+] |
| InChI | InChI=1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1 |
| InChIKey | AEQFSUDEHCCHBT-UHFFFAOYSA-M |
| Safety Phrases |
Classification: Caution- Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | Sodium Valproate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-357) |
Biological Description
| Alternative Names | 2-Propylpentanoic acid Na |
| Research Areas | Cancer, Cell Signaling |
| PubChem ID | 16760703 |
| Scientific Background |
Sodium Valproate is a clinically established anticonvulsant that has garnered significant attention in neuroscience and neurodegenerative disease research due to its multifaceted pharmacological profile. As a histone deacetylase (HDAC) inhibitor (IC50 = 400 µM), it modulates epigenetic regulation, influencing gene expression patterns critical to neuronal survival and plasticity. Preclinical studies have demonstrated its neuroprotective properties, including the inhibition of amyloid-beta (Aβ) production and reduction of neuritic plaque formation—key pathological features of Alzheimer’s disease. Its anti-inflammatory and anticancer activities further underscore its therapeutic versatility. Sodium Valproate continues to be a focal point in translational neuroscience, offering insights into epigenetic therapies for brain health and disease. |
| References |
1. Phiel C.J., et al. (2001) J. Biol. Chem. 276: 36734. 2. Kim H.J., et al. (2007) J. Pharmacol. Exp. Ther. 321: 892. 3. Qing H., et al. (2008) J. Exp. Med. 205: 2781. |
Product Images
Chemical structure of Sodium Valproate (SIH-357), a HDAC inhibitor. CAS #: 1069-66-5. Molecular Formula: C8H15NaO2 . Molecular Weight: 166.2 g/mol.
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