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| Product Name | Sorafenib |
| Description |
Raf-1 kinase inhibitor |
| Purity | >99% |
| CAS No. | 284461-73-0 |
| Molecular Formula | C21H16ClF3N4O3 |
| Molecular Weight | 464.8 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble inDMSO (200mg/ml) or ethanol (3mg/ml) |
| Source | Synthetic |
| Appearance | Off white powder |
| SMILES | CNC(=O)c1cc(ccn1)Oc2ccc(cc2)NC(=O)Nc3ccc(c(c3)C(F)(F)F)Cl |
| InChI | InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) |
| InChIKey | MLDQJTXFUGDVEO-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Sorafenib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-476) |
Biological Description
| Alternative Names | 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; 4-methylbenzenesulfonic acid |
| Research Areas | Cell Signaling |
| PubChem ID | 216239 |
| Scientific Background | Sorafenib is a multi-kinase inhibitor that targets several receptor tyrosine kinases including VEGFR, PDGFR, and Raf kinases. While primarily developed as an anticancer agent, Sorafenib is increasingly used in neuroscience to study angiogenesis, neurovascular remodeling, and kinase signaling in the brain. Its ability to modulate VEGF and Raf pathways makes it relevant in models of neuroinflammation, glioblastoma, and blood-brain barrier dysfunction. Sorafenib is a valuable tool for investigating the intersection of vascular and neuronal signaling in neurodegenerative disease research. |
| References | 1. Juan, L., et al. (2014) Environmental Toxic. Pharm. 38(2): 438–443. |
Product Images
Chemical structure of Sorafenib (SIH-476), a Raf-1 inhibitor (and other kinases). CAS #: 2884461-73-0. Molecular Formula: C21H16ClF3N4O3. Molecular Weight: 464.8 g/mol.
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