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| Product Name | SP600125 |
| Description |
Jnk inhibitor |
| Purity | >98% |
| CAS No. | 129-56-6 |
| Molecular Formula | C14H8N2O |
| Molecular Weight | 220.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO or methanol |
| Source | Synthetic |
| Appearance | Yellow to brown solid |
| SMILES | C1=CC=C4C3=C1C(=O)C2=CC=CC=C2C3=N[NH]4 |
| InChI | InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) |
| InChIKey | ACPOUJIDANTYHO-UHFFFAOYSA-N |
| Safety Phrases |
Classification: D2B - Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H315 - Causes skin irritation. H319 - Causes serious eye irritation. H335 - May cause respiratory irritation Precautionary Phrases: P261 - Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 - Wash skin thoroughly after handling. P271 - Use only outdoors or in a well-ventilated area. P280 - Wear protective gloves/ eye protection/ face protection. P302 + P352 - IF ON SKIN: Wash with plenty of soap and water. P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 – Call a POISON CENTER or doctor/ physician if you feel unwell. P321 - Specific treatment (see supplemental first aid instructions on this label). P332 + P313 - If skin irritation occurs: Get medical advice/ attention. P337 + P313 - If eye irritation persists: Get medical advice/ attention. P362 - Take off contaminated clothing and wash before reuse. P403 + P233 - Store in a well - ventilated place. Keep container tightly closed. P405 - Store locked up. P501 - Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | SP600125 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-381) |
Biological Description
| Alternative Names | Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone |
| Research Areas | Apoptosis, Cancer, Cell Signaling |
| PubChem ID | 8515 |
| Scientific Background | SP600125 is a selective, reversible inhibitor of c-Jun N-terminal kinases (JNK1, JNK2, and JNK3), with IC50 values ranging from 40 to 90 nM. JNK signaling is implicated in neuronal apoptosis, neuroinflammation, and synaptic dysfunction—hallmarks of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. SP600125 is frequently used to dissect the role of JNK in neuronal cell death pathways and to evaluate neuroprotective strategies. Although it exhibits reduced selectivity under certain conditions, its in vivo activity and minimal off-target effects on ERK2 and p38β make it a valuable tool for studying stress-activated kinase signaling in the brain. SP600125 has also shown protective effects in models of ischemia-reperfusion injury, supporting its relevance in stroke and neurovascular research. |
| References |
1. Bennett B.L., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(24): 13681-6. 2. Schnabl B., et al. (2001) Hepatology. 34(5): 953-63. 3. Bain J., et al. (2003) Biochem. J. 371(Pt 1): 199-204. 4. Wang Y., et al. (2007) Life Sci. 80(22): 2067-75. |
Product Images
Chemical structure of SP600125 (SIH-381), a Jnk inhibitor. CAS #: 129-56-6. Molecular Formula: C14H8N2O. Molecular Weight: 220.2 g/mol.
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Based on validation through cited publications.