Sphingosine

Protein Kinase C inhibitor

Catalog No. SIH-202

5.00 out of 5 based on 1 customer rating
CAS No. 123-78-4
Molecular Formula C18H37NO2
SKU: SIH-202 Categories: ,

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SIH-202_Sphingosine_Chemical_Structure.png
Product Name Sphingosine
Description

Protein Kinase C inhibitor

Purity >98%
CAS No. 123-78-4
Molecular Formula C18H37NO2
Molecular Weight 299.49
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO
Source Synthetic
Appearance Solid
SMILES CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO)N)O
InChI InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1
InChIKey WWUZIQQURGPMPG-KRWOKUGFSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Sphingosine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-202)

Biological Description

Alternative Names (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
PubChem ID 5280335
Scientific Background Sphingosine is a bioactive lipid and precursor to ceramide and sphingosine-1-phosphate, both of which are critical regulators of cell fate. In the nervous system, sphingosine modulates signaling pathways involved in neuroinflammation, apoptosis, and synaptic function. It selectively inhibits protein kinase C and calmodulin-dependent enzymes, influencing neurotransmission and neuronal survival. Alterations in sphingolipid metabolism are associated with neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease, making sphingosine a molecule of interest in neurobiology.
References 1. Radin N. (2003) Biochem J. 371(Pt2): 243-256.
2. Carter H.E., Glick F.J., Norris W.P., Phillips G.E. (1947) J Biol Chem. 170: 285-295.

Product Images

<p>Chemical structure of Sphingosine (SIH-202), a Protein Kinase C inhibitor. CAS #: 123-78-4. Molecular Formula: C18H37NO2. Molecular Weight: 299.49 g/mol.</p>

Chemical structure of Sphingosine (SIH-202), a Protein Kinase C inhibitor. CAS #: 123-78-4. Molecular Formula: C18H37NO2. Molecular Weight: 299.49 g/mol.

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